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research Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17

31 citations , March 2010 in “Molecular Endocrinology”

Androgens like testosterone increase colon muscle contractions by affecting calcium pathways.

research Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties

May 2026 in “Discover Oncology”

Targeting LGR4 may help treat cancer by reducing cancer stem cell traits and drug resistance.

research Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: review.

January 2019 in “PubVet”

research Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule

January 2025 in “Biochemical Pharmacology”

Peficitinib can turn human fibroblasts into cells that help grow hair.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

research Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype

24 citations , May 2019 in “PLOS genetics”

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

research Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor

37 citations , August 2011 in “Journal of Bone and Mineral Research”

A girl had rickets due to a gene mutation affecting vitamin D response.

research 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Not having enough cystatin M/E protein causes less hair growth and dry skin.

research 507 Trial to investigate the role of ATP-sensitive potassium channels (KATPc) in dermal papilla cells (DPCs)

November 2024 in “Journal of Investigative Dermatology”

ATP-sensitive potassium channels are important for hair growth.

research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle

January 2007

research Cystic panfolliculoma of the conchal bowl

March 2026 in “Dermatology Online Journal”

Cystic panfolliculoma is a rare, harmless tumor that can be confused with other skin tumors.

research Characterization of hairless (Hr) and FGF5genes provides insights into the molecular basis of hair loss in cetaceans

50 citations , February 2013 in “BMC evolutionary biology”

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

research Loss of Memo, a novel FGFR regulator, results in reduced lifespan

27 citations , September 2013 in “The FASEB Journal”

Losing Memo protein shortens lifespan and affects health.

research KERATIN 17-related recessive atypical pachyonychia congenita with variable hair and tooth anomalies

3 citations , June 2022 in “European journal of human genetics”

A new type of pachyonychia congenita linked to a specific keratin gene mutation was found in two Pakistani families.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research IRF2BP2 genes provide new insights into coat type and fiber composition variation in sheep

February 2026 in “Small Ruminant Research”

The IRF2BP2 gene affects sheep fleece quality by influencing fiber traits.

research CircRNA-1926 Promotes the Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis

16 citations , September 2020 in “Animals”

circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

research Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

40 citations , December 2012 in “PLoS ONE”

Removing Ctip2 in skin cells causes skin inflammation similar to atopic dermatitis.

research Congenital Adrenal Hyperplasia

13 citations , July 2009 in “Pediatrics in Review”

Early diagnosis and treatment of congenital adrenal hyperplasia are crucial to manage symptoms and prevent complications.

research A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

15 citations , March 2022 in “Frontiers in Bioengineering and Biotechnology”

Fucoidan may help treat lung cancer by altering gene expression in cancer cells.

research Past and Future Strategies for GPCR Deorphanization

1 citations , July 2010

Finding functions for unknown GPCRs is hard but key for making new drugs.

research Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling

5 citations , May 2024 in “Developmental Cell”

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

research LncRNA MTC enhances the proliferation of Liaoning cashmere goat skin fibroblasts by modulating GSTM1-ASK1 interaction

March 2024 in “Cytologia”

LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.

research Expression ofSfrp2Is Increased in Catagen of Hair Follicles and Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

research Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche

3 citations , December 2024 in “Stem Cell Reports”

Low fucosylation boosts stem cell growth in the eye.

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations , January 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia

10 citations , June 2011 in “Movement Disorders”

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

research Expression of Calcyclin, a Calcium-Binding Protein, in the Keratogenous Region of Growing Hair Follicles

40 citations , March 1991 in “Journal of Investigative Dermatology”

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