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Did you mean Chronic Leg Ulcers?

GlossaryChronic Leg Ulcers

long-lasting leg sores that don't heal within six weeks

Chronic leg ulcers are long-lasting sores or wounds on the legs that fail to heal within a typical timeframe, usually defined as six weeks or more. They are often caused by underlying conditions such as poor blood circulation, diabetes, or venous insufficiency, and can lead to significant pain, infection, and reduced quality of life if not properly managed.

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research Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine

56 citations , March 2016 in “International Wound Journal”

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

research Ankle Range of Motion, Leg Pain, and Leg Edema Improvement in Patients With Venous Leg Ulcers

4 citations , January 2016 in “JAMA Dermatology”

Compression therapy improved ankle movement, reduced leg swelling, and lessened pain in patients with venous leg ulcers.

research Hair-follicle Transplant Into Chronic Ulcers: A New Graft Concept

6 citations , June 2017 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

Transplanting hair follicles into chronic ulcers helps them heal better.

research Topical application of cellulose membrane for the treatment of non-healing venous leg ulcers

April 2026 in “Frontiers in Bioengineering and Biotechnology”

Cellulose membranes heal venous leg ulcers faster than standard dressings.

research Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety

3 citations , June 2025 in “Gyemyeong uidae haksulji”

PDRN is effective and safe for healing wounds and skin issues.

research Adjunctive treatment for leg ulcers

January 2014 in “Indian dermatology online journal”

Different treatments help heal leg ulcers depending on their type, with new therapies showing promise for chronic wounds.

research Obesity and the skin: Skin physiology and skin manifestations of obesity

405 citations , May 2007 in “Journal of The American Academy of Dermatology”

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

research Editor's Picks August 2023

July 2023 in “Journal of the European Academy of Dermatology and Venereology”

Anti-IL17A therapy reduced venous leg ulcer size by 64% without major side effects.

research LB1154 Rising antimicrobial resistance in chronic wounds

July 2025 in “Journal of Investigative Dermatology”

DACC-based dressings are more effective than silver-based ones for treating chronic wounds with antimicrobial resistance.

research 527 PTEN is a master driver of healing inhibition in venous leg ulcers by targeting immune response, angiogenesis and lymphangiogenesis

November 2024 in “Journal of Investigative Dermatology”

Targeting PTEN can improve healing in venous leg ulcers.

research Autologous smashed follicular dermal graft with epidermal cell suspension in chronic nonhealing leg ulcers

3 citations , January 2020 in “Journal of Cutaneous and Aesthetic Surgery”

A new treatment using skin and hair cells may help heal stubborn leg ulcers effectively and safely.

research Regeneration of Chronic Wounds with Allogeneic Platelet Gel versus Hydrogel Treatment: a Prospective Study

25 citations , January 2018 in “Acta Clinica Croatica”

Allogeneic platelet gel heals chronic wounds better than hydrogel.

research Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

188 citations , February 2023 in “International Journal of Molecular Sciences”

Flavonoids can help heal wounds effectively due to their beneficial properties.

research Reflections on how wound healing-promoting effects of the hair follicle can be translated into clinical practice

43 citations , July 2014 in “Experimental Dermatology”

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

research Interrelation of immunity and tissue repair or regeneration

252 citations , April 2009 in “Seminars in Cell & Developmental Biology”

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

research The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study

15 citations , January 2018 in “Acta dermato-venereologica”

Skin treatment can lower life quality for patients with skin conditions.

research The use of platelet‐rich plasma in wound healing and vitiligo: A systematic review and meta‐analysis

August 2023 in “Skin Research and Technology”

Platelet-rich plasma (PRP) may improve healing in chronic wounds and vitiligo and promote hair regrowth, but more research is needed.

research Current Indications of Low-Level Laser Therapy in Plastic Surgery: A Review

15 citations , May 2015 in “Photomedicine and Laser Surgery”

Low-Level Laser Therapy may help with flap survival and burn scar healing, but not with venous ulcers or hair loss, and more research is needed.

Regenerative Surgery in the Management of Leg Ulcers

research Regenerative Surgery in the Management of the Leg Ulcers

15 citations , January 2016 in “Journal of cell science & therapy”

Using a patient's own tissue for micro-grafts may effectively treat non-healing leg ulcers and relieve pain.

research Ten years of injectable platelet‐rich fibrin

November 2023 in “Periodontology 2000”

Injectable platelet-rich fibrin has improved healing and regeneration in various medical fields and can be more effective than previous treatments.

Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways

research Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways

5 citations , October 2025 in “International Journal of Nanomedicine”

Traditional Chinese Medicine and biomaterials help heal chronic wounds by targeting multiple pathways.

research The skin and obesity

January 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences”

Obesity worsens skin health and losing weight can improve skin conditions.

research Zinc in skin pathology and care

35 citations , January 2006 in “Journal of Dermatological Treatment”

Zinc can help with some skin problems, but its effectiveness varies depending on the condition.

research Innovative Uses for Zinc in Dermatology

27 citations , May 2010 in “Dermatologic Clinics”

Zinc can be a helpful secondary treatment for certain skin conditions, but more research is needed to guide its use.

research Skin disorders in elderly subjects

27 citations , July 2015 in “International Journal of Dermatology”

Every elderly patient had at least one skin condition, often linked to other diseases, highlighting the need for integrated skin and general healthcare in the elderly.

research Thymosin β4 Promotes Dermal Healing

28 citations , January 2016 in “Vitamins and hormones”

Thymosin β4 helps improve skin healing and reduce scarring.

research Dermatology

1 citations , February 2004

Skin diseases are common and can significantly affect people's lives; better outcome measures and ethical clinical trials are needed to improve dermatology care.