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GlossaryCollagen IV

forms part of basement membrane supporting various tissues

Collagen IV, also known as Type IV Collagen, is a crucial protein that forms part of the basement membrane, a thin layer that supports and separates cells in various tissues, including the skin, blood vessels, and organs. It provides structural support and plays a key role in tissue repair and cellular functions, making it essential for maintaining the integrity and function of these tissues.

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research Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting Type III collagen synthesis and hair follicle regeneration in skin injury

June 2025 in “Materials Today Bio”

A silk fibroin hydrogel boosts wound healing and hair growth by increasing collagen and hair follicles.

research Synergistic Effects of Fractional CO ₂ Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

January 2025 in “Dermatologic Therapy”

Combining fractional CO₂ laser with type III collagen improves acne scar treatment.

research DAB-labelling for collagen type III and PDGFR as control on equine skin sections.

November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

DAB labeling effectively identifies collagen type III and PDGFR in horse skin, but may show false positives.

research Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing

24 citations , September 2024 in “Journal of Investigative Dermatology”

research Eco-engineered recombinant collagen III-PEG hydrogels with curcumin synergy for accelerated skin regeneration: A green crosslinking strategy in wound therapeutics

September 2025 in “International Journal of Biological Macromolecules”

The new hydrogel with curcumin speeds up wound healing safely and effectively.

research Immunofluorescent localization of collagen types I, III and IV, fibronectin, laminin, and basement membrane proteoglycan in developing mouse skin

20 citations , July 1987 in “Development Genes and Evolution”

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

Tideglusib may help bone regeneration without being toxic at low doses.

research Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin

1 citations , December 2025 in “International Journal of Molecular Sciences”

Atelocollagen boosts collagen production and improves skin elasticity in aged skin.

research Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)

7 citations , May 2023 in “Animals”

Fraser's dolphins heal wounds exceptionally well, with their skin's collagen returning to normal after injury.

research 1375 Effects of a new recombinant human collagen on skin aging

April 2023 in “Journal of Investigative Dermatology”

The new recombinant human collagen can help slow skin aging and repair skin, while also controlling inflammation.

Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

research Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth

June 2025 in “Frontiers in Bioengineering and Biotechnology”

Recombinant collagen with nicotinamide boosts hair growth and health.

research Immunolocalization of typeIII collagen in normal and recovering traumatic skins of guinea pigs

January 1993 in “Di-Si Junyi Daxue xuebao”

Type III collagen increases in recovering guinea pig skin, aiding tissue stability.

research Table 1_Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth.docx

June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

The RHC complex with nicotinamide promotes hair growth and health.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research Improved cutaneous wound healing after intraperitoneal injection of alpha‐melanocyte‐stimulating hormone

29 citations , November 2014 in “Experimental Dermatology”

Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.

Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation

research Skin-permeable liposome improved stability and permeability of bFGF against skin of mice with deep second degree scald to promote hair follicle neogenesis through inhibition of scar formation

26 citations , September 2018 in “Colloids and Surfaces B: Biointerfaces”

A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

research Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing

21 citations , July 2020 in “Stem Cell Research & Therapy”

Fat stem cells from diabetic mice can still help heal wounds.

research Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche

5 citations , July 2023 in “World Journal of Stem Cells”

The hydrogel promotes better wound healing by creating a fetal-like environment.

research Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model

3 citations , May 2025 in “Lasers in Surgery and Medicine”

Microneedle radiofrequency helps skin repair and rejuvenate by activating fibroblasts and remodeling the skin's structure.

research ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion

1 citations , January 2025 in “Journal of Cosmetic Dermatology”

Inhibiting ACE2 improves skin regeneration during tissue expansion.

Investigating the Role of Various Extracellular Matrix in Androgenetic Alopecia: Insights from Immunostaining and Quantitative Analysis - A Pilot Study

research Investigating the role of various extracellular matrix in androgenetic alopecia: Insights from immunostaining and quantitative analysis – A pilot study

October 2024 in “Dermatologica Sinica”

ECM changes may play a role in hair loss, with differences between males and females.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research 965 In search of the common mechano-chemical pathways during the regeneration of spiny (acomys cahirinus) and laboratory (mus musculus) mouse skin

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Spiny mice regenerate skin better than laboratory mice due to larger hair bulges, more stem cells, and different collagen ratios.

research 1469 Tissue mechanics partake in spatiotemporal patterning of wound-induced hair neogenesis in African spiny mouse

April 2018 in “Journal of Investigative Dermatology”

African spiny mice can regenerate skin and hair after wounds due to specific tissue mechanics.

research Smooth muscle cell expression of a constitutive active form of human Profilin1 accelerates cutaneous wound repair

April 2011 in “The FASEB Journal”

Profilin1 speeds up wound healing.

Sprayable Supramolecular Hydrogel with Minimalism for Wilderness First Aid: Integration of Mechanical Performance and Biofunctionality

research Sprayable supramolecular hydrogel with minimalism for wilderness first aid: integration of mechanical performance and biofunctionality

March 2026 in “Collagen and Leather”

The hydrogel speeds up wound healing and fights bacteria, making it great for emergency use.