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GlossaryCollagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research Basement membrane Laminin and Type IV Collagen in Various Benign and Malignant Adnexal Tumors of the Skin: An Immunohistochemical Study

28 citations , October 1984 in “Journal of Investigative Dermatology”

research <p>Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study</p>

34 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.

research Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting Type III collagen synthesis and hair follicle regeneration in skin injury

June 2025 in “Materials Today Bio”

A silk fibroin hydrogel boosts wound healing and hair growth by increasing collagen and hair follicles.

research Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

July 2025 in “Cosmetics”

Recombinant type XVII collagen may help regrow hair by activating specific cell pathways.

research Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified

125 citations , August 1992 in “Development”

Implanted dermal papillae can induce hair growth in rat ear wounds.

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

Tideglusib may help bone regeneration without being toxic at low doses.

Screening and Expression Validation of Key Proteins for Secondary Hair Follicle Growth in Cashmere Goats Based on iTRAQ Quantitative Proteomics Technology

research Screening and expression validation of key proteins for secondary hair follicle growth in cashmere goats based on iTRAQ quantitative proteomics technology

October 2024 in “Frontiers in Veterinary Science”

FKBP10 and FBN2 are key proteins for hair growth in cashmere goats.

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

research Regional Variations in the Histology of Porcine Skin

44 citations , November 2014 in “Tissue Engineering Part C Methods”

Porcine skin varies by region, affecting its use as a human skin model.

research Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

March 2024 in “Clinical, cosmetic and investigational dermatology”

Skin Radiance Collagen improved skin and hair health in adult females.

research Network pharmacological study of ethyl acetate fraction of Ophioglossum vulgatum Linn. in alopecia treatment

December 2022 in “Research Square (Research Square)”

The ethyl acetate fraction of Ophioglossum vulgatum Linn. may promote hair growth and could be a new herbal treatment for hair loss.

Essential Fatty Acid Deficiency in a Patient with Vascular Ehlers-Danlos Syndrome

research Essential Fatty Acid Deficiency (EFAD) in a Patient with Vascular Ehlers Danlos Syndrome (EDS-4) (P12-053-19)

1 citations , June 2019 in “Current developments in nutrition”

A patient with Ehlers-Danlos Syndrome improved after treatment for fat malabsorption and essential fatty acid deficiency.

research Cultured dermal papilla cells of the rat vibrissa follicle. Proliferative activity, adhesion properties and reorganization of the extracellular matrix in vitro

27 citations , December 1997 in “Archives of Dermatological Research”

Rat dermal papilla cells have unique properties and interact differently with their environment compared to other skin cells.

research Melanocytes from the Outer Root Sheath of Hair Follicles Cultivated on Collagen Membrane Improve their Melanotic Properties

5 citations , January 2012 in “Journal of Tissue Science & Engineering”

Collagen membranes improve melanocyte growth for treating skin depigmentation.

Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

research Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth

June 2025 in “Frontiers in Bioengineering and Biotechnology”

Recombinant collagen with nicotinamide boosts hair growth and health.

research 707 Guiding skin organoid generation via extracellular matrix cues and spatially controlled morphogen gradients

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists improved how to make skin-like structures from stem cells using special gels and a device that controls growth signals, leading to better hair and skin features.

research Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration

42 citations , April 2016 in “Plastic and reconstructive surgery/PSEF CD journals”

The hydrogel with fractionated PRP improves skin regeneration by enhancing wound healing and growth of skin structures.

research In vitro and ex vivo examination of topical Pomiferin treatments

10 citations , February 2014 in “Fitoterapia”

Pomiferin may improve skin and hair by increasing important protein production.

research Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

October 2025 in “Cell Proliferation”

IL10_ApoEVs improve skin healing and reduce scarring.

research Alpaca (Vicugna pacos) Skin Analyzed Under Architecture and Structure

April 2024 in “UNESP Institutional Repository (São Paulo State University)”

Alpaca skin has glands, hair follicles, and different collagen types.

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

Type IV collagen chains vary in different parts of human skin, with specific patterns linked to melanocytes.

Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device

research Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device

March 2024 in “Advanced healthcare materials/Advanced Healthcare Materials”

Scientists developed a new way to create skin-like structures from stem cells using a special 3D gel and a device that improves cell organization and increases hair growth.