research Epithelial barrier function: assembly and structural features of the cornified cell envelope
The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.
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30 / 1000+ resultsresearch Expression of epidermal keratins and filaggrin during human fetal skin development.
Keratins and filaggrin change as fetal skin develops, marking key stages of skin formation.
research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation
N-WASP is essential for healthy skin and preventing inflammation.
research Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid
Salicylic acid can safely exfoliate and regenerate skin without causing inflammation.
research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System
The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.
research Fine Structure of the Fully Keratinized Hair Cuticle in the Head Hair of the Human
Human hair cuticle has five cell layers with specific junctions and granules.
research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy
Keratin-associated proteins are part of the developing hair fiber cuticle.
research Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia
The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
research EFFECT OF ESTRADIOL LOCALLY APPLIED TO ABNORMAL SKIN
Applying estradiol to skin causes local changes but not cancer.
research Local IL-17 orchestrates skin aging
Blocking IL-17 signaling can delay skin aging and improve skin and hair health.
research The structure of the cornified claw sheath in the domesticated cat (Felis catus): implications for the claw‐shedding mechanism and the evolution of cornified digital end organs
Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.
research Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes
Sciellin is a protein that helps form protective layers in skin, hair, and nails.
research Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes
A wide range of proteins are integrated into the skin's protective layer.
research Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines
Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.
research Novel insights into hair structure and the effects of chemical stressors on hair and skin using label-free advanced light microscopy
Chemical stressors damage hair structure but the skin's outer layer protects living cells.
research Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution
Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.
research The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein
Trichohyalin is a versatile protein involved in hair and skin structure.
research Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization
Fos protein is crucial for cell transition to cornification in keratinized tissues.
research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.
Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
research Embryonic keratinization in vertebrates in relation to land colonization
Keratinization in embryos helped vertebrates adapt to land by forming a protective skin barrier.
research An improved and rapid method to construct skin equivalents from human hair follicles and fibroblasts
Researchers created a quick, cost-effective way to make skin-like tissue from hair follicles and fibroblasts.
research Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes
Involucrin is a useful marker for keratinocyte differentiation in mice.
research Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.
Too much keratin 16 in mice skin causes abnormal skin thickening and structure.
research Circle Hairs in a Patient with Multiple Myeloma
An elderly woman with cancer improved after treatment for a rare skin condition with coiled hairs.
research EFFECTS OF STEROID HORMONES ON DEVELOPING MOUSE SKIN IN VITRO
Cortisol and corticosterone thin mouse skin and regress hair follicles, while testosterone promotes skin and hair development.
research A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification
A gene mutation in mice causes skin defects and early death.
research Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium
Pax9 is crucial for proper tongue surface development and preventing skin-like changes.
research Herstellung eines Hautäquivalentes mit Hilfe von humanen Zellen der Haarwurzelscheide und Fibroblasten
A skin model using hair and skin cells can mimic human skin for research.
research Formation of the cornified envelope
The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
research Embryologic layers in dermatology: Developmental checkpoint disorders, diagnostic insight, and regenerative futures
Understanding embryologic layers improves skin disorder diagnosis and supports developing targeted therapies.