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The chapter provides a comprehensive case study on the development of Exo.Reset®, a cosmetic product designed for skin rejuvenation using extracellular vesicle (EV) technology. It highlights the application of international Good Practices and guidelines, such as MISEV2013 and South Korea's 2024 guidelines, to ensure scientific rigor and regulatory compliance. The research and development process includes EV isolation, purification, characterization, and in vitro assessments with human dermal fibroblast cultures, focusing on gene expression changes related to skin rejuvenation. The study emphasizes quality control, reproducibility, and ethical considerations, offering a model for integrating EV technology into cosmetics and advancing skin care innovations.

The study evaluated the effectiveness of various hair care products in removing and preventing pollution-related deposits on hair and skin using in vivo and in vitro models. Researchers used artificial sebum mixed with Carbon Black particles to simulate pollution effects and tested 42 shampoo formulas, finding cleanability efficiencies ranging from 5% to 100%. Additionally, 45 hair care products were assessed for their ability to prevent carbon particle deposition, with coverage percentages between 2% and 16%. The study concluded that the new protocols effectively quantified the performance of hair care products in cleansing and protecting hair from pollution, supporting the development of new cosmetic products to mitigate pollution's impact on hair properties. The research was supported by L'Oréal, with all authors affiliated with the company.