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GlossaryCXCR7

protein receptor involved in cell signaling and hair follicle regulation

CXCR7, also known as C-X-C chemokine receptor type 7, is a protein that functions as a receptor for certain signaling molecules called chemokines. It plays a role in various biological processes, including cell migration, immune response, and tissue repair. In the context of hair biology, CXCR7 has been implicated in the regulation of hair follicle cycling and may influence conditions like alopecia.

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Preconditioning With Far-Infrared Irradiation Enhances Proliferation, Cell Survival, And Migration Of Rat Bone Marrow-Derived Stem Cells Via CXCR4-ERK Pathways

research Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways

44 citations , October 2017 in “Scientific Reports”

Far-infrared radiation improves stem cell growth and movement, helping heart therapy.

research Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation

March 2026 in “Preprints.org”

Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.

research CXCL12 inhibits hair growth through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

research PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus

71 citations , May 2019 in “Rheumatology”

Tph cells are linked to the severity of systemic lupus erythematosus.

research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

70 citations , December 2008 in “Cancer Research”

CXCR2 in skin cells promotes tumor growth.

research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata

64 citations , July 2016 in “Journal of Immunology”

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

research Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

1 citations , October 2019

Neutrophils are important for causing chronic itch in atopic dermatitis, and blocking the CXCR3 receptor may reduce this itch.

research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration

October 2025 in “Cell Reports”

Regulatory T cells help hair growth by using the Cxcr4-Cxcl12 pathway.

research Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

July 2019

Neutrophils are key in causing chronic itch in atopic dermatitis, and blocking CXCR3 could reduce this itch.

research 744 Role of Sdf1-Cxcr4 signaling in mouse appendage regeneration

April 2016 in “Journal of Investigative Dermatology”

Mice without the p21 gene can fully regenerate injured ears due to reduced Sdf1 increase and leukocyte recruitment, suggesting new ways to induce tissue regeneration in mammals.

research Insights into the context-dependent immunological roles of the CXCL12–CXCR4 axis in alopecia

April 2026 in “Frontiers in Immunology”

Blocking the CXCL12–CXCR4 axis may help treat hair loss in alopecia.

research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

48 citations , January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Chemokine signaling is important for hair development.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , February 2024 in “The Journal of Experimental Medicine”

CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.

research Scarless wound healing: finding the right cells and signals

132 citations , June 2016 in “Cell and Tissue Research”

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

research The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

57 citations , April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research Type 1 interferon signature in the scalp lesions of alopecia areata

52 citations , March 2010 in “British Journal of Dermatology”

Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2

research Antroquinonol Exerts Immunosuppressive Effect on CD8⁺ T Cell Proliferation and Activation to Resist Depigmentation Induced by H₂O₂

11 citations , January 2017 in “Oxidative medicine and cellular longevity”

Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.

research Alopecia areata possibly induced by autoimmune reaction in a patient with human T‐cell lymphotropic virus‐1‐associated myelopathy

6 citations , May 2013 in “The Journal of Dermatology”

Autoimmune reactions may cause both alopecia areata and HAM.

Skin Wound Healing: Role of Bone Marrow Stem Cells in Regeneration

research Skin Wound Healing

5 citations , January 2016 in “Elsevier eBooks”

Using a specific binding agent and low doses of FK506 can stimulate stem cells, speeding up skin healing by 25% and improving skin quality in rats and mice.

research Granulocyte colony stimulating factor promotes scarless tissue regeneration

4 citations , September 2024 in “Cell Reports”

Granulocyte colony stimulating factor helps heal wounds without scars.

research Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata

3 citations , January 2016 in “Journal of Clinical & Cellular Immunology”

Targeting CXCL10 may help treat alopecia areata.

research The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling

July 2025

Blocking CXCR4 may help treat hidradenitis suppurativa.

research 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics

July 2025 in “Journal of Investigative Dermatology”

Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.

Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions in Mouse, Dog, and Human Reveals Conserved Drivers of Primary Cicatricial Alopecia

research Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia

January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Potential therapeutic targets for scarring hair loss are identified.

research Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian

June 2024 in “Archives of Dermatological Research”

SFRP2 and PTGDS may be key factors in female hair loss.

research Comprehensive transcriptome profiling between balding and non-balding scalp of Female pattern hair loss in Asian

February 2024 in “Research Square (Research Square)”

The research suggests that SFRP2 and PTGDS proteins might be indicators of female pattern hair loss and could contribute to hair loss.

research Author response: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

February 2023

ILC1-like cells may contribute to hair loss in alopecia areata.

research Decision letter: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

September 2022

ILC1-like cells may contribute to hair loss in alopecia areata and could be new treatment targets.