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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

hsa_circ_0002980 can help stop liver cancer cells from growing and spreading.

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

The Potts-Guy model best predicts skin permeability for the tested drugs.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Finasteride is mostly broken down in the body and excreted in urine and feces.

Measuring 24-OHase induction helps identify defects in vitamin D processing and predict treatment response.

Diphencyprone can cause unexpected and possibly permanent vitiligo.

Cyproterone acetate plus ethinyl estradiol is generally more effective in treating hirsutism, but consider side effects and patient characteristics.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

A more sensitive assay was developed to detect enzyme activity converting arginine to citrulline in hair follicles.

The ABCG2 gene variant increases the risk of high uric acid and cholesterol, especially in overweight or obese young Mexican males.

Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.

COX-2 levels change during the hair cycle and affect skin and hair growth.

The new method makes finasteride production cheaper and safer for industry.

Reliable method detects finasteride in human plasma at low doses.

The process effectively regenerates the Pd/C catalyst for finasteride synthesis.

Human liver enzyme DHEA ST helps process minoxidil.

Adults with classic congenital adrenal hyperplasia value medication that prevents weight gain from glucocorticoids the most.

The new compound may be a safer alternative to finasteride for prostate protection.

Many medications may be linked to cognitive disorders, but most lack warnings on labels.

Cardiovascular drugs can cause various skin problems, so recognizing these reactions is important.

Two finasteride tablet types are equally effective and can be swapped.

The inhibitor affects androgen metabolism but not ovarian function.

Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.

CTP-543 effectively promotes hair regrowth in adults with moderate to severe alopecia areata.

The method effectively measures drug impact on DHT levels in prostate treatments.

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.