12 citations
,
May 2023 in “EMBO reports” High mTORC1 activity slows hair growth and causes it to lose color.
The digital system for measuring melasma shows promise but needs more development for better accuracy and automation.
May 2004 in “International Journal of Cosmetic Science” Melanogenesis inhibitors like kojic acid and niacinamide can reduce inflammation and pigment production in skin cells.
48 citations
,
June 2000 in “Japanese Journal of Cancer Research” Dimethylarsinic acid speeds up skin tumor growth in certain mice.
14 citations
,
April 2005 in “Experimental Dermatology” Stressed fibroblasts greatly increase melanin production in hair, skin, and eye cells, mainly due to a growth factor called bFGF.
July 2025 in “Scientific Reports” Dermal papilla cell-conditioned medium can help reduce skin aging caused by oxidative stress.
4 citations
,
March 2013 in “The American Journal of Cosmetic Surgery” Melanin absorbing light is necessary but not enough for effective hair removal by light treatment.
July 2019 in “Indian dermatology online journal” Alopecia areata can show unusual red-dotted vessels and dithranol treatment may mask typical patterns.
6 citations
,
June 1994 in “Journal of Animal Science” None of the tested compounds created a permanent mark on cattle.
January 1974 in “OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)” Oxidative stress causes hair graying by damaging hair follicle melanocytes more than skin melanocytes.
June 2025 in “British Journal of Dermatology” Segmented hair color changes can indicate active alopecia areata.
January 2011 in “Journal of Liaoning University of Traditional Chinese Medicine” Balancing Yin and Yang can help treat hair loss.
216 citations
,
October 1997 in “American Journal of Ophthalmology” Using the eye pressure medication latanoprost can cause excessive hair growth and darker eyelashes on the treated eye.
2 citations
,
June 1972 in “PubMed” 35 citations
,
October 2003 in “Dermatologic clinics” Laser therapy on darker skin has higher risks and needs expert handling.
4 citations
,
November 2021 in “Molecular Medicine Reports” Combining narrow-band ultraviolet B light and stem cell transplantation helps repigmentation in vitiligo by maintaining calcium balance in mice.
October 2025 in “Research Square (Research Square)” Enhancing blood vessel interactions with hair cells may help treat hair loss and skin aging.
4 citations
,
July 2021 in “Skin Appendage Disorders” Sudden hair whitening may be linked to immune system activity.
4 citations
,
May 2023 in “Pigment Cell & Melanoma Research” BMI1 is essential for preventing hair greying and maintaining hair color.
October 2023 in “Dermatology practical & conceptual” Folliculitis Decalvans and Frontal Fibrosing Alopecia can coexist in people with darker skin, showing features of both conditions.
15 citations
,
January 2017 in “Pigment International” Early hair graying is often inherited and influenced by genetics, environment, and lifestyle, but treatment options are limited.
6 citations
,
December 1989 in “Journal of the American Academy of Dermatology” Minoxidil lotion can cause hair discoloration.
23 citations
,
May 2017 in “Journal of the American Academy of Dermatology” FFA patients have fewer melanocytes and thinner skin compared to others.
94 citations
,
October 2017 in “International Journal of Dermatology” Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.
November 2022 in “Journal of Investigative Dermatology” Blocking mTORC1 activity could increase hair pigmentation and potentially reverse greying.
77 citations
,
January 1980 in “Carcinogenesis” TPA is about 50 times more effective at promoting tumors than MZ.
1 citations
,
January 2009 in “Elsevier eBooks” Laser hair removal can be effective for darker skin but requires careful use to avoid side effects.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” Grey hair is wilder, drier, and less manageable than pigmented hair.
September 2023 in “Journal of the American Academy of Dermatology” Spanish speakers with limited English search most for "pigmentation/dark spots."