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GlossaryDCAF17 gene

gene involved in protein regulation and linked to hair loss

The DCAF17 gene provides instructions for making a protein that is involved in various cellular processes, including the regulation of other proteins. Mutations in this gene have been linked to a rare genetic disorder called Woodhouse-Sakati syndrome, which can cause hair loss (alopecia), diabetes, and other symptoms.

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Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene

research Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene

3 citations , December 2021 in “Frontiers in endocrinology”

A new mutation in the DCAF17 gene was found in a Chinese family, causing Woodhouse-Sakati syndrome and diabetes.

research Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family

1 citations , September 2021 in “Frontiers in genetics”

A genetic mutation in the DCAF17 gene caused Woodhouse-Sakati syndrome in a Chinese patient from a related family.

research Woodhouse-Sakati Syndrome: The New Genetic Variant of DCAF17 In 2 Adult Sisters

1 citations , July 2024 in “JCEM Case Reports”

A new genetic variant of Woodhouse-Sakati syndrome was found in two adult sisters in Russia.

research Phenotypic Variability of c.436delC DCAF17 Gene Mutation in Woodhouse-Sakati Syndrome

14 citations , March 2018 in “The American journal of case reports”

People with the same genetic mutation for Woodhouse-Sakati syndrome can have different symptoms.

research Novel splicing‐site mutation in DCAF17 gene causing Woodhouse‐Sakati syndrome in a large consanguineous family

4 citations , December 2021 in “Journal of clinical laboratory analysis”

A new mutation in the DCAF17 gene was found to cause Woodhouse-Sakati syndrome in a large family.

The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

research The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

7 citations , January 2015 in “Case reports in genetics”

Using SNP array testing helped quickly find the gene causing Woodhouse-Sakati syndrome in two related individuals.

research Endocrine disorders in Woodhouse-Sakati syndrome: a systematic review of the literature

31 citations , January 2014 in “Journal of endocrinological investigation”

Woodhouse-Sakati syndrome often causes sexual development issues, hair loss, learning disabilities, deafness, muscle contractions, limb pain, and diabetes.

Woodhouse-Sakati Syndrome: A Case Study of Three Saudi Sisters

research Woodhouse-Sakati syndrome (WSS)

5 citations , November 2021 in “Saudi medical journal”

The document reports three sisters with Woodhouse-Sakati syndrome showing typical symptoms and unusual gynecological anomalies.

research Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods”

1 citations , August 2021 in “Canadian journal of neurological sciences”

Woodhouse-Sakati syndrome can cause writer's cramp and other varied symptoms, highlighting the importance of genetic testing for diagnosis.

research Woodhouse-Sakati syndrome: genotype–phenotype review and case of intra-familial heterogeneity

July 2024 in “Journal of Rare Diseases”

Woodhouse-Sakati syndrome shows varied symptoms and genetic differences within families.

research Woodhouse-Sakati Syndrome Due to the Rare DCAF17 c.321+1G>A Mutation: The Second Case Report Worldwide

May 2026 in “Cureus”

A rare genetic mutation causes Woodhouse-Sakati syndrome symptoms.

research Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs

2 citations , November 2024 in “PLoS ONE”

Genomic prediction can improve breeding strategies for Korean Sapsaree dogs.

research Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing

1 citations , March 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Low-coverage sequencing is a cost-effective way to identify genes related to wool traits in rabbits.

research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

research Woodhouse-Sakati Syndrome with Unique Unreported Previous Findings

July 2021 in “Scholars Journal of Medical Case Reports”

Woodhouse-Sakati Syndrome can include unique symptoms like liver issues and low growth hormone.

Expansion of the Spectrum of ITGB6-Related Disorders to Adolescent Alopecia, Dentogingival Abnormalities, and Intellectual Disability

research Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability

19 citations , December 2015 in “European Journal of Human Genetics”

A rare ITGB6 gene variant causes intellectual disability, hair loss, and dental issues.

research Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing

5 citations , November 2022 in “Genetics selection evolution”

Low-coverage sequencing is a cost-effective way to find genetic factors affecting rabbit wool traits.

research Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

3 citations , April 2023 in “Veterinary sciences”

Researchers found genes that may explain why some pigs grow winter hair, which could help breed cold-resistant pigs.

research C2orf37 mutational spectrum in Woodhouse–Sakati syndrome patients

43 citations , April 2010 in “Clinical genetics”

Truncating mutations in the C2orf37 gene cause Woodhouse–Sakati syndrome.

Progress on Genome-Wide Association Studies and Selection Signature Analysis for Agronomic Traits in Chinese Sheep and Goats: Review

research Progress on genome-wide association studies and selection signature analysis for agronomic traits in Chinese sheep and goats: review

October 2025 in “Animal Bioscience”

Key genes linked to important traits in Chinese sheep and goats have been identified, but challenges remain in breeding improvements.

research Genome-Wide Associations with Body and Fleece Weight in United States Sheep

June 2025 in “Genes”

Certain genetic markers can help predict wool production in U.S. sheep.

research Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep

June 2024 in “Cells”

Editing the FGF5 gene in sheep increases fine wool growth.

research Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?

July 2024 in “International Journal of Molecular Sciences”

MicroRNAs could help assess and manage multiple chronic diseases.

research Table_1_Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.xlsx

November 2021 in “OPAL (Open@LaTrobe) (La Trobe University)”

Melatonin may treat rosacea and Alzheimer's by reducing inflammation and affecting blood vessel growth.

Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles

research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles

7 citations , June 2022 in “Czech Journal of Animal Science”

Certain circular RNAs help cashmere goats grow more hair.

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Related Terms

Research

research Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene

research Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family

research Woodhouse-Sakati Syndrome: The New Genetic Variant of DCAF17 In 2 Adult Sisters

research Phenotypic Variability of c.436delC DCAF17 Gene Mutation in Woodhouse-Sakati Syndrome

research Novel splicing‐site mutation in DCAF17 gene causing Woodhouse‐Sakati syndrome in a large consanguineous family

research The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

research Endocrine disorders in Woodhouse-Sakati syndrome: a systematic review of the literature

research Woodhouse-Sakati syndrome (WSS)

research Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods”

research Woodhouse-Sakati syndrome: genotype–phenotype review and case of intra-familial heterogeneity

research Woodhouse-Sakati Syndrome Due to the Rare DCAF17 c.321+1G>A Mutation: The Second Case Report Worldwide

research Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs

research Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing

research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

research Woodhouse-Sakati Syndrome with Unique Unreported Previous Findings

research Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability

research Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing

research Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

research C2orf37 mutational spectrum in Woodhouse–Sakati syndrome patients

research Progress on genome-wide association studies and selection signature analysis for agronomic traits in Chinese sheep and goats: review

research Genome-Wide Associations with Body and Fleece Weight in United States Sheep

research Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep

research Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?

research Table_1_Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.xlsx

research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles

research Polyglandular autoimmune syndrome type 4 with GAD antibody and dystonia

research FOXP3 ⁺ regulatory T cells and age‐related diseases

research PROTACs: A novel strategy for cancer drug discovery and development

research Protein degradation: expanding the toolbox to restrain cancer drug resistance

research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions