515 citations
,
April 2003 in “Endocrine Reviews” Androgens and DHEA can help prevent breast cancer and improve health in women.
403 citations
,
November 2005 in “Journal of Endocrinology” Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.
219 citations
,
January 2006 in “Drug Metabolism Reviews” DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
168 citations
,
January 2005 in “Journal of Investigative Dermatology” Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.
96 citations
,
September 1975 in “The Journal of Clinical Endocrinology & Metabolism” Hormone levels change during puberty, leading to physical developments like pubic hair and voice changes.
95 citations
,
September 1979 in “Acta Paediatrica” Girls have higher DHEA levels earlier in puberty than boys, indicating earlier development.
52 citations
,
March 1987 in “Journal of the American Academy of Dermatology” High DHEA-S levels may cause hair loss in young men.
49 citations
,
January 2009 in “The Journal of Clinical Endocrinology & Metabolism” DHEA treatment helps grow pubic hair and boosts mood in girls with adrenal issues.
35 citations
,
January 2018 in “Vitamins and hormones” DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.
28 citations
,
March 1973 in “The Journal of Clinical Endocrinology & Metabolism” Altered DHEA metabolism in hair follicles may be linked to hair loss in balding men.
27 citations
,
April 2007 in “European Journal of Pharmacology” Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.
27 citations
,
May 2002 in “The Journal of Clinical Endocrinology & Metabolism” Brothers of women with PCOS tend to have higher levels of a hormone called DHEAS, indicating a possible genetic link.
22 citations
,
January 2015 in “The Cochrane library” DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.
18 citations
,
November 1998 in “Comparative biochemistry and physiology. Part A, Molecular & integrative physiology” Changes in prolactin and DHEA levels are not required for the start of mink hair growth cycles.
18 citations
,
January 1990 in “Journal of The American Academy of Dermatology” Lower doses of dexamethasone can safely reduce high DHEAS levels in women with androgenic disorders.
14 citations
,
June 2011 in “Steroids” New compounds may help treat prostate issues without affecting androgen receptors.
12 citations
,
December 2020 in “Comprehensive psychoneuroendocrinology” Hormone levels in hair change during pregnancy, with progesterone increasing significantly compared to non-pregnant women.
12 citations
,
March 2000 in “Clinical Chemistry” Chronic DHEA supplementation slightly increases testosterone in hair but stays within safe limits.
11 citations
,
August 2000 in “Journal of Endocrinology” DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.
11 citations
,
June 1979 in “British Journal of Dermatology” The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.
10 citations
,
November 2018 in “Developmental Psychobiology” Hair can effectively measure DHEA and testosterone levels in children.
9 citations
,
February 2004 in “Veterinary Dermatology” Canine hair follicle cells metabolize DHEA and testosterone differently than human cells.
7 citations
,
December 1971 in “European Journal of Endocrinology” Human hair follicles can process steroid hormones like DHEA.
7 citations
,
January 1971 in “Archives of Dermatological Research” 5 citations
,
January 1993 in “Hormone and Metabolic Research” DHEA and DHEA-S help maintain underarm hair in older women.
3 citations
,
January 2011 in “International journal of trichology” Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.
1 citations
,
January 2023 in “Journal of Obstetrics and Gynaecology” High DHEA and short cervical length in women with PCOS and recurrent miscarriages may harm pregnancy outcomes.
1 citations
,
February 2022 in “The Journal of Urology” Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
1 citations
,
January 1988 Topical DHEA safely increases skin oil production.
1 citations
,
November 2024 in “European Journal of Endocrinology” Higher childhood DHEAS levels are linked to advanced puberty and DNA changes.