research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes
Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.
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research Hormonal therapies for acne
Hormonal treatments can improve acne, but they come with potential side effects and risks.
research 181 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial
Sandalore, a synthetic scent, was found to reduce hair loss and improve hair growth in women with hair shedding issues.
research A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l -carnitine to prevent and treat hair loss: A prospective investigation
The lotion with equol, dihomo-γ-linolenic acid, and propionyl-l-carnitine was effective in reducing hair loss in men and women.
research Effects of Oral Contraceptives Containing Desogestrel and Drospirenone on Clinical, Hormonal, and Metabolic Parameters of the Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial
Oral contraceptives with desogestrel and drospirenone improve PCOS symptoms.
research 440 Squaric acid dibutylester, used in alopecia areata immunotherapy, promotes innate immune-driven hair growth with CD206+ macrophage accumulation in the dermis
research Other Antiandrogens
Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.
research Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism*
The ovary mainly causes high testosterone in PCO, while the adrenal gland is the main source in IH.
research Telogen effluvium treated with Serenoa repens supplement
A supplement with Serenoa repens improved hair loss in a patient.
research Discoid lupus erythematosus exacerbated by contact dermatitis caused by use of squaric acid dibutylester for topical immunotherapy in a patient with alopecia areata
Topical squaric acid dibutylester worsened discoid lupus erythematosus in a patient.
research Effect of a Serenoa repens extract on human primary hair dermal papilla cells isolated from male and female donors
Serenoa repens extract may help hair growth in both men and women.
research Die kontrazeptive Betreuung androgenisierter Frauen mit einem niedrig dosierten cyproteronacetathaltigen Einphasenpräparat
Diane is effective for treating acne, seborrhoea, androgenic alopecia, and mild hirsutism in women.
research Modern approach to the treatment of patients with androgen-dependent dermatopathies
Cyproterone acetate improves skin symptoms and quality of life in women with androgen-related issues.
research Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study
Myo-inositol with magnesium effectively reduces acne and hirsutism in PCOS patients without side effects.
research News & Notes
Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.
research A multicenter evaluation of 10% sulfacetamide sodium in a 10% urea vehicle scalp treatment lotion and a 10% urea deep cleansing antibacterial shampoo for the treatment of seborrheic dermatitis of the scalp
The lotion and shampoo effectively treated scalp seborrheic dermatitis.
research Spironolactone therapy in hypertrichosis
Spironolactone may help treat excessive hair growth in girls, but more research is needed.
research Estranys matins de febrer: Pauline Fondevila
Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.
research 60058 Change in patient-reported hair satisfaction during deuruxolitinib treatment of severe alopecia areata: Pooled data from the Phase 3 THRIVE-AA1 and THRIVE-AA2 trials
Deuruxolitinib significantly improves hair satisfaction in severe alopecia areata patients.
research Is spironolactone better than finasteride for symptoms of hirsutism in transgender women?
Spironolactone and finasteride are equally effective for hirsutism in transgender women.
research Treatment of hirsutism with spironolactone
Spironolactone is effective and safe for treating excessive facial hair in women.
research Clascoterone as a novel treatment for androgenetic alopecia
Clascoterone may be a promising treatment for hair loss.
research Use of spironolactone in treatment of hirsutism
Spironolactone may reduce excessive hair growth in women.
research Comparative Evaluation of Topical Betamethasone Dipropionate Lotion 0.05% versus its Combination with Intralesional Triamcinolone Acetonide Injection in Alopecia Areata: A Randomised Controlled Trial
Combining injections with lotion is more effective for hair regrowth in alopecia areata than using the lotion alone.
research Clinical effectiveness of ethinylestradiol-cyproterone acetate and raloxifene combination therapy in polycystic ovary syndrome-associated infertility
The combination therapy effectively treats infertility in PCOS without major side effects.
research Design and Validation of a Sensitive Multisteroid LC-MS/MS Assay for the Routine Clinical Use: One-Step Sample Preparation with Phospholipid Removal and Comparison to Immunoassays
The new LC-MS/MS method is more accurate and reliable than traditional immunoassays for measuring steroids in serum.
research The Administration of Flumethasone, by Three Different Routes, its Measurement in the Plasma and Some Effects on Wool Growth in Merino Wethers
Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.
research TRADITIONAL AND ALTERNATIVE METHODS OF ACNE TREATMENT
Spironolactone and clascoterone are promising acne treatments with fewer side effects.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Anti-androgen Treatments
For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.