36 citations
,
July 2020 in “Frontiers in Medicine” Spironolactone might help protect against severe lung problems in COVID-19 patients.
34 citations
,
September 2020 in “BMC Endocrine Disorders” Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.
32 citations
,
February 2017 in “Oncotarget” Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.
29 citations
,
May 2018 in “Clinical Endocrinology” Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.
27 citations
,
June 2015 in “Revista Brasileira de Farmacognosia” Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.
26 citations
,
December 2017 in “Journal of Investigative Dermatology” Disrupting Notch signaling in blood vessels increases scarring during wound healing in mice.
25 citations
,
January 2019 in “Annals of Dermatology” Blocking the NOTCH pathway can prevent fibrosis in systemic sclerosis.
24 citations
,
October 2017 in “Biomolecules” Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.
24 citations
,
January 2012 in “Journal of Cellular Biochemistry” C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.
23 citations
,
October 2005 in “Journal of The American Academy of Dermatology” Two transplant patients on cyclosporine unexpectedly developed hair loss.
14 citations
,
March 2022 in “Journal of inflammation research” Baricitinib shows promise as a new treatment for certain skin conditions like alopecia areata.
14 citations
,
October 2018 in “PloS one” Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.
14 citations
,
January 2017 in “Pharmacological Reports” TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.
13 citations
,
December 2024 in “Cellular and Molecular Life Sciences” Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.
13 citations
,
September 2024 in “Frontiers in Pharmacology” Morroniside has many health benefits, including protection against diabetes complications, bone and brain diseases, heart and skin issues, and it supports hair growth and reduces inflammation.
13 citations
,
December 2012 in “Frontiers in bioscience” Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.
10 citations
,
May 2024 in “npj Regenerative Medicine” Umbilical cord cells may help delay skin aging.
10 citations
,
May 2019 in “International Journal of Environmental Research and Public Health” Finasteride may cause kidney damage.
8 citations
,
February 2023 in “American Journal of Physiology-Cell Physiology” Adiponectin and bradykinin play important roles in skin health and may help treat skin conditions.
8 citations
,
August 2020 in “PLOS Computational Biology” A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.
7 citations
,
January 2022 in “Evidence-based complementary and alternative medicine” Ginger supplements helped reduce symptoms and improve metabolic health in hypothyroid patients.
7 citations
,
June 2021 in “Amino acids” Human hair protein modifications could potentially indicate heart disease risk.
7 citations
,
January 2020 in “Postepy Dermatologii I Alergologii” Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.
6 citations
,
April 2019 in “Journal of Pediatric Endocrinology and Metabolism” Metformin improved menstrual cycle regularity and signs of hyperandrogenism in adolescent girls with type 1 diabetes but did not improve blood sugar control.
5 citations
,
January 2016 in “Journal of The American Academy of Dermatology” Skin doctors should know about skin and kidney disease links to prevent serious kidney problems.
4 citations
,
June 2006 in “Primary Care” The document recommends a team-based approach and personalized care for managing diabetes in teenagers.
3 citations
,
July 2025 in “BIOMED natural and applied science” Drug repurposing can create safer, cheaper treatments by finding new uses for existing drugs.
3 citations
,
January 2025 in “Scientific Reports” Cepharanthine is safe but not effective in significantly reducing COVID-19 recovery time.
3 citations
,
January 2024 in “Signal transduction and targeted therapy” Lymphatic vessels are essential for health and can be targeted to treat various diseases.
3 citations
,
October 2023 in “Frontiers in physiology” ceRNA networks offer potential treatments for skin aging and wound healing.