November 2025 in “Journal of Investigative Dermatology” The study investigates the effects of N,N-Dimethylglycine sodium salt (DMG-Na) on human skin cells, revealing its potential as a multifaceted skin treatment. DMG-Na promotes cell proliferation, migration, and VEGF release in HaCaT keratinocytes, while exhibiting anti-inflammatory and antioxidant properties in models of skin diseases. It increases intracellular calcium and nitric oxide production in HDMECs, enhancing skin blood flow. In dermal papilla cells, DMG-Na reverses senescence-associated changes, indicating anti-aging benefits. A pilot study with a 1% DMG-Na gel confirmed its vasodilatory effects. These findings suggest DMG-Na could treat various skin conditions, including hair loss, with further clinical studies underway to assess its broader therapeutic potential.
7 citations
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March 1990 in “Pigment Cell Research” Certain chemicals cause hair graying in black mice but not yellow mice.
56 citations
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November 1958 in “The Journal of Cell Biology” A unique skin cell similar to hair bulb melanocytes was identified, with better preservation using permanganate fixation.
2 citations
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January 2018 in “Biomolecules & therapeutics” Polyamidoamine dendrimers can change the strength and direction of electroosmotic flow through the skin, affecting drug delivery.
1 citations
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January 2016 in “Journal of Advanced Plastic Surgery Research” The laser treatment effectively reduced hair growth in women with hirsutism, with temporary side effects.
27 citations
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July 1983 in “Journal of Investigative Dermatology” Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.
2 citations
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January 2022 in “BioMed Research International” LED light therapy at 863 nm wavelength can slow down skin tumor growth and reduce inflammation in mice.
February 2023 in “Cosmoderma” Combining red LED therapy with beta-carotene is more effective for treating photoaging than red LED therapy alone.
1 citations
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January 1988 Topical DHEA safely increases skin oil production.
20 citations
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April 2019 in “BioMed Research International” Treatments with sunscreen and active ingredients can reduce skin hyperpigmentation by decreasing DNA methylation.
April 2016 in “Journal of The American Academy of Dermatology” Daylight photodynamic therapy is effective and well-tolerated for treating actinic keratoses with minimal side effects.
2 citations
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January 2019 in “Recent Advances in Biology and Medicine” A 5% DMSO and 5% BSA mix best preserves rabbit dermal papilla cells during cryopreservation.
May 1981 in “Inpharma (Balgowlah)” Medroxyprogesterone acetate improved sleep apnea symptoms in some obese patients.
7 citations
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April 1996 in “Archives of dermatological research” Topical tacalcitol can treat psoriasis by acting directly on skin cells.
March 2026 in “Mendeley Data” March 2026 in “Mendeley Data” July 2024 in “Journal of Investigative Dermatology” PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.
July 1996 in “Clinical and Experimental Dermatology” Putting calcipotriol ointment on the skin once doesn't change calcium levels in the body right away.
15 citations
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February 2011 in “Experimental Dermatology” Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.
January 2026 in “British Journal of Dermatology” Caffeine and DMG increase calcium influx in hair follicle cells without being toxic.
2 citations
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September 2019 in “Journal of the American Academy of Dermatology” USB videodermatoscopes are a practical and affordable alternative for diagnosing skin conditions.
522 citations
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January 2001 in “Cancer investigation” Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Different types of human skin cells respond uniquely to various colors and doses of light, which could lead to specialized light treatments for skin conditions.
January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” The adapalene-benzoyl peroxide gel works better and faster for acne treatment than using either ingredient alone, with manageable side effects.
11 citations
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August 2021 in “Stem Cell Research & Therapy” Pimecrolimus reduces the effectiveness of stem cell therapy for atopic dermatitis.
10 citations
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February 2008 in “International Journal of Andrology” A combination of nanomilled oral testosterone and dutasteride normalized testosterone levels in men with low testosterone and is safe for short-term use.
81 citations
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July 2012 in “Translational Psychiatry” Memantine may slightly improve memory in people with Down syndrome, but more research is needed.
DHEA inhibits growth in both mouse and human melanoma cells but works differently in each.
6 citations
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February 2025 in “International Journal of Molecular Sciences” The new system greatly improves carvedilol's solubility and effectiveness.