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GlossaryDiphenylcyclopropenone

topical immunotherapy agent used to treat alopecia areata

Diphenylcyclopropenone (DPCP) is a topical immunotherapy agent used primarily to treat alopecia areata, a condition that causes hair loss. It works by inducing a mild allergic reaction on the scalp, which is thought to distract the immune system from attacking hair follicles, thereby promoting hair regrowth.

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Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: A retrospective case series

44 citations , February 2015 in “Journal of the American Academy of Dermatology”

Combining diphenylcyclopropenone with anthralin is more effective for hair regrowth in alopecia areata than using diphenylcyclopropenone alone, but may cause more side effects.

research Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients

41 citations , November 2015 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Diphenylcyclopropenone (DPCP) can help regrow hair in many alopecia areata patients but may cause side effects and relapses.

research Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population

36 citations , May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

research Systematic review and quality analysis of studies on the efficacy of topical diphenylcyclopropenone treatment for alopecia areata

21 citations , June 2017 in “Journal of The American Academy of Dermatology”

Topical DPCP is somewhat effective for hair loss in alopecia areata, but more research is needed.

research Efficacy and safety of anthralin in combination with diphenylcyclopropenone in the treatment of alopecia areata: a retrospective case series

20 citations , June 2019 in “Archives of dermatological research”

Combining DPCP and anthralin helps regrow hair in some alopecia areata patients.

research Diphenylcyclopropenone in patients with alopecia areata. A critically appraised topic

19 citations , October 2015 in “British Journal of Dermatology”

Diphenylcyclopropenone's effectiveness and safety for alopecia areata are unclear.

research Videocapillaroscopic Pattern of Alopecia Areata before and after Diphenylciclopropenone Treatment

17 citations , October 2011 in “International Journal of Immunopathology and Pharmacology”

DPCP treatment improved hair regrowth and increased new capillaries in alopecia areata patients.

research Severe dermographism after topical therapy with diphenylcyclopropenone for alopecia universalis

16 citations , April 2000 in “Contact dermatitis”

A man developed severe skin reactions after using a treatment for hair loss.

research Alopecia areata in a Patient with Candidiasis-Endocrinopathy Syndrome: Unsuccessful Treatment Trial with Diphenylcyclopropenone

16 citations , January 1995 in “Dermatology”

The treatment for alopecia areata with diphenylcyclopropenone was unsuccessful.

research Clinical efficacy of diphenylcyclopropenone in alopecia areata: Retrospective data analysis of 50 patients

14 citations , August 2014 in “Journal of the American Academy of Dermatology”

Diphenylcyclopropenone (DPCP) is effective in treating alopecia areata, with most patients showing significant hair regrowth.

research Treatment of chronic extensive alopecia areata by diphenylcyclopropenone alone versus in combination with anthralin

10 citations , June 2019 in “Dermatologic therapy”

DPCP alone is more effective and safer for treating chronic extensive alopecia areata than combining it with anthralin.

research Efficacy of diphenylcyclopropenone in alopecia areata: a comparison of two treatment regimens

10 citations , January 2018 in “Postępy Dermatologii i Alergologii”

Treating alopecia areata every 3 weeks with diphenylcyclopropenone is more effective than weekly treatments.

research Phototherapy as a Useful Therapeutic Option in the Treatment of Diphenylcyclopropenone-induced Vitiligo

10 citations , January 2010 in “Acta dermato-venereologica”

Light therapy can effectively treat vitiligo and hair loss caused by a specific medication.

Possible Advantage of Imiquimod and Diphenylcyclopropenone Combined Treatment Versus Diphenylcyclopropenone Alone: An Observational Study of Nonresponder Patients With Alopecia Areata

research Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata

9 citations , April 2016 in “Australasian journal of dermatology”

Combining imiquimod with diphenylcyclopropenone may improve treatment outcomes for alopecia areata patients who don't respond to diphenylcyclopropenone alone.

research Efficacy of topical diphenylcyclopropenone maintenance treatment for patients with alopecia areata: A retrospective study

8 citations , January 2018 in “Journal of the American Academy of Dermatology”

Diphenylcyclopropenone treatment helps prevent hair loss relapse in alopecia areata patients.

research Diphenylcyclopropenone-Induced Vitiligo in a Patient with Alopecia Universalis

4 citations , August 2013 in “Case reports in dermatology”

A patient with total hair loss developed vitiligo after using a treatment called DCP.

research Use of diphenylcyclopropenone for alopecia areata treatment during pregnancy

3 citations , April 2024 in “JAAD Case Reports”

DPCP may be safe for treating alopecia during pregnancy, but more research is needed.

research Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis

3 citations , July 2023 in “International Journal of Trichology”

DPCP can help regrow hair in some people with severe alopecia.

research Economic Impact of Home-Use versus Office-Use Diphenylcyclopropenone in Extensive Alopecia Areata

3 citations , November 2021 in “Skin Appendage Disorders”

Home-use treatment for severe alopecia areata is as effective as office-use but costs half as much.

research Comparative Study between The Efficacy and Safety of Topical Immune Therapy with Diphenylcyclopropenone versus Anthralin in The Treatment of Resistant Alopecia Areata

2 citations , May 2024 in “International Journal of Medical Arts”

Diphenylcyclopropenone (DPCP) is more effective than anthralin for treating resistant alopecia areata.

research Diphenylcyclopropenone alleviates trachyonychia in alopecia universalis

2 citations , May 2024 in “International Journal of Dermatology”

research Topical Immunotherapy with Diphenylcyclopropenone in Paediatric Patients with Alopecia Areata—A Retrospective Study of 97 Patients

1 citations , August 2024 in “Skin Health and Disease”

Topical immunotherapy with DPCP led to some hair regrowth in most pediatric alopecia areata patients, especially those with milder cases and longer treatment.

research Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata

1 citations , August 2024 in “Journal of Pharmacy & Pharmaceutical Sciences”

The DPCP/HPβCD complex improves solubility and anti-inflammatory effects for alopecia areata treatment.

research Diphenylcyclopropenone Treatment Outcomes for Alopecia Areata

1 citations , February 2023 in “Deleted Journal”

Diphenylcyclopropenone is effective for treating alopecia areata but has a high relapse rate.

research A case report of verruca vulgaris on basis of alopecia areata successfully treated with diphenylcyclopropenone

1 citations , January 2017 in “International journal of trichology”

Diphenylcyclopropenone (DPCP) effectively treated both alopecia areata and verruca vulgaris.

Randomized Controlled Trial to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasma in Alopecia Areata

research Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasmain Alopecia Areaata

January 2025 in “International Journal of Trichology”

Combining DPCP with PRP doesn't improve hair regrowth in alopecia areata.

research Diphenylcyclopropenone in severe alopecia areata in children and adolescents: long-term follow-up and relapse rate

May 2024 in “Journal of the Egyptian Womenʼs Dermatologic Society”

Diphenylcyclopropenone is effective and safe for treating severe alopecia areata in children, with maintenance therapy reducing relapse risk.

research Preparation and Evaluation of Topical Formulation of Diphenylcyclopropenone for the Treatment of Alopecia Areata

June 2023 in “International Journal of Clinical Research and Reports”

Method B with propylene glycol is better for stable low-concentration DPCP solutions for alopecia areata.

The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systematic Review and Meta-Analysis

research The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systemic Review and Meta-Analysis

January 2023 in “Dermatologic therapy”

Diphenylcyclopropenone topical immunotherapy is effective for treating alopecia areata, with some side effects.

Comparative Trial on Efficacy of Topical Contact Immunotherapy with Dinitrochlorobenzene and Diphenylcyclopropenone in Alopecia Areata

research Comparative trail on efficacy of topical contact immunotherapy with dinitrochlorobenzene and diphenylcyclopropenone in alopecia areata

July 2021 in “International journal of dermatology, venereology and leprosy sciences”

Diphenylcyclopropenone is more effective and has fewer side effects than dinitrochlorobenzene for treating alopecia areata.