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GlossaryDoxorubicin

chemotherapy drug that interferes with cancer cell DNA

Doxorubicin, also known as Adriamycin, is a chemotherapy drug used to treat various types of cancer, including breast cancer, bladder cancer, and lymphoma. It works by interfering with the DNA inside cancer cells, preventing them from growing and dividing. However, it can also cause side effects such as hair loss (alopecia) and damage to the heart, so its use is carefully monitored by healthcare professionals.

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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

1461 citations , March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

research Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy

522 citations , January 2001 in “Cancer investigation”

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

research Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer

108 citations , December 2003 in “Clinical breast cancer”

PLD is an effective and safer alternative for treating breast cancer.

research Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

102 citations , October 2010 in “Molecular Pharmaceutics”

Copper-doxorubicin nanoparticles effectively treat tumors with less toxicity.

research Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin

76 citations , March 2005 in “Cancer Research”

Doxorubicin can block blood vessels from hair follicles, reducing skin tumor growth.

Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling

research Prevention of doxorubicin-induced alopedia by scalp hypothermia: relation to degree of cooling.

53 citations , June 1982 in “The BMJ”

Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.

Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

research Minoxidil (Mx) as a prophylaxis of doxorubicin – induced alopecia

49 citations , October 1994 in “Annals of Oncology”

Minoxidil not effective in preventing chemotherapy-induced hair loss.

research The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

19 citations , March 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research High-dose alpha-tocopherol as a preventive of doxorubicin-induced alopecia.

18 citations , October 1986 in “PubMed”

Alpha-tocopherol does not prevent hair loss from doxorubicin.

Doxorubicin-Induced Hair Loss in the Angora Rabbit: A Study of Treatments to Protect Against Hair Loss

research Doxorubicin-induced hair loss in the Angora rabbit: a study of treatments to protect against the hair loss

12 citations , December 1987 in “Cancer Chemotherapy and Pharmacology”

Vitamin E in the diet might help protect against hair loss caused by the chemotherapy drug doxorubicin in rabbits.

Chinese Herbal Medicine, Guilu Erxian Glue, as Alternative Medicine for Adverse Side Effects of Chemotherapy in Doxorubicin-Treated Cell and Mouse Models

research Chinese Herbal Medicine, Guilu Erxian Glue, as Alternative Medicine for Adverse Side Effects of Chemotherapy in Doxorubicin-Treated Cell and Mouse Models

9 citations , April 2021 in “Evidence-based complementary and alternative medicine”

Guilu Erxian Glue may help reduce chemotherapy side effects like weight loss and heart stress.

Analysis of Adverse Drug Reactions and Their Severity in Breast Cancer Patients Treated with the Docetaxel-Doxorubicin Regimen at Sultan Agung Islamic Hospital

research ANALYSIS OF ADVERSE DRUG REACTIONS (ADRs) AND THEIR SEVERITY IN BREAST CANCER PATIENTS TREATED WITH THE DOCETAXEL-DOXORUBICIN REGIMEN AT SULTAN AGUNG ISLAMIC HOSPITAL

July 2025 in “Jurnal Farmasi Sains dan Praktis”

Most adverse reactions to the treatment were mild, with nausea being the most common.

research Abstract P1-12-19: A case report of successful hair preservation using scalp cooling with doxorubicin and cyclophosphamide during pregnancy

June 2025 in “Clinical Cancer Research”

Scalp cooling can effectively prevent hair loss during chemotherapy in pregnancy.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Streptomyces-derived nano-doxorubicin: Clinical status and patents granted

January 2024 in “Scripta Medica”

Nanoparticle delivery can reduce side effects of the cancer drug doxorubicin.

Early Detection of Doxorubicin-Induced Cardiotoxicity in Minipigs Using Magnetic Resonance Imaging

research Détection précoce de la cardiotoxicité due à la doxorubicine chez le miniporc par imagerie par résonance magnétique

August 2016 in “PolyPublie (École Polytechnique de Montréal)”

Doxorubicin causes heart damage, so early detection and monitoring are important during chemotherapy.

research TRAIL sensitization of PC3 prostate cancer cells by doxorubicin can be blocked by the anti-oxidant N-acetyl-cysteine or by the iron chelator deferoxamine

October 2006 in “Clinical Cancer Research”

Antioxidants can block the cancer-fighting effects of doxorubicin.

research A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

12 citations , September 2015 in “Drug Design Development and Therapy”

AD198 is more effective than doxorubicin in stopping certain dog cancer cells.

research Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin

63 citations , February 2013 in “Human cell”

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

research Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

5 citations , January 2014 in “Advances in bioscience and biotechnology”

Natural honey protects against Doxorubicin's harmful effects.

research A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo

27 citations , January 2018 in “Drug Delivery”

GC10/DOX hydrogel shows promise as an effective thyroid cancer treatment.

research Determination of the Effects of Eruca sativa Oil, Sodium Carbonate, Lavender Oil and Aloe vera Oil on Lipid Profile and Breast Tumour Markers in Breast Cancer-induced Doxorubicin Treated Female Albino Rats

2 citations , February 2020 in “Annual Research & Review in Biology”

Eruca sativa oil, Aloe vera oil, and sodium carbonate may help improve cholesterol and tumor markers in breast cancer treatment.

Postoperative Chemotherapy and Tamoxifen Compared with Tamoxifen Alone in the Treatment of Positive-Node Breast Cancer Patients Aged 50 Years and Older with Tumors Responsive to Tamoxifen: Results from the National Surgical Adjuvant Breast and Bowel Project B-16

research Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16.

279 citations , June 1990 in “Journal of Clinical Oncology”

Adding chemotherapy to tamoxifen improves survival for older breast cancer patients with positive nodes.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

$Doxil (Caelyx): An Exploratory Study with Pharmacokinetics in Patients with Hormone-Refractory Prostate Cancer$

research Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer

81 citations , February 2000 in “Anti-cancer drugs”

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.

research Mitoxantrone

60 citations , June 1997 in “Drugs & Aging”

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

research Skin toxicity determined in vitro by three-dimensional, native-state histoculture.

54 citations , March 1991 in “Proceedings of the National Academy of Sciences”

This model can replace animal testing for quick, cost-effective skin toxicity tests.

research Cutaneous Reactions to Chemotherapeutic Agents

53 citations , May 2001 in “The American journal of the medical sciences”

Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.

research Chemotherapy-Induced Alopecia

52 citations , May 1993 in “Southern Medical Journal”

Imuvert can prevent some chemotherapy-induced hair loss.

research Chemotherapy Targets the Hair-Follicle Vascular Network but Not the Stem Cells

45 citations , July 2006 in “Journal of Investigative Dermatology”

Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.