research Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.
Overexpressing COX-2 in mice skin reduces skin tumor development.
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research Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis
Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
research Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles
ASC-CM is more effective than EV for treating osteoarthritis.
research 의이인의 정유 분획물이 모유두 세포의 성장에 미치는 영향
ECS may help treat hair loss by promoting hair cell growth.
research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers
Blocking EGFR in skin cells doesn't majorly increase inflammation markers.
research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation
Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
research 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells
Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.
research Ovine placental steroid synthesis and metabolism in late gestation†
Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.
research UV light may induce hypertrichosis through production of PGE2
UV light might cause excessive hair growth by increasing PGE2 in the skin.
research Small Molecule Inhibitors and Inflammatory Skin Diseases
New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.
research 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice
Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.
research Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate
TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.
research 269 Down-regulatory role of cholecystokinin on psoriatic epidermal inflammation
Cholecystokinin may help reduce skin inflammation in psoriasis.
research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands
The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.
research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Abnormal ECM and immune cell interactions can cause skin diseases.
research Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease
Platelet-released growth factors can reduce inflammation in joint disease.
research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles
Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
research 498 Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT
DHT may reduce inflammation caused by certain bacteria in skin cells.
research Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?
Enhancing cannabinoid signaling may help treat skin inflammation.
research Local stimulation of sebaceous gland activity by the topical administration of dehydroepiandrosterone
Topical DHEA safely increases skin oil production.
research The significance of CYP11A1 expression in skin physiology and pathology
CYP11A1 is crucial for skin health and disease by producing important steroids.
research Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy
Neurosteroids may help prevent seizures in epilepsy.
research Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin
Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.
research Assessment of chemokines MIP-1α and MIP-1 βin Iraqi women with polycystic ovarian syndrome
PCOS is linked to low-grade chronic inflammation.
research Comprehensive Evaluationof Tectonagrandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-ReductaseInhibition and Anti-Inflammatory Properties
Tectona grandis leaves may help treat hair loss and inflammation.
research Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production
Omega-6 fats in certain cells boost male hormone production.
research Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines
Some Korean herb extracts can reduce inflammation and are safe for skin use.
research Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling
Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.
research eLife assessment: Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
Enterococcus faecalis delays wound healing by disrupting cell functions and creating an anti-inflammatory environment.
research Glia-derived steroids modulate epileptogenesis in a model of temporal lobe epilepsy
Neurosteroids from glia cells help control seizure development in epilepsy.