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January 2016 in “Journal of Stem Cell Research & Therapy” Notch1 signaling is crucial for improving wound healing and skin regeneration by affecting stem cell behavior.
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January 2020 in “BioMed Research International” Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.
October 2025 in “International Journal of Molecular Sciences” Extracellular vesicles from mammary cells help heal skin wounds effectively.
February 2026 in “International Journal of Recent Surgical and Medical Sciences” Human exosomes are effective for targeted treatments but face scalability issues, while plant exosomes are cost-effective for cosmetics.
April 2023 in “Journal of Investigative Dermatology” POUF51 and HES3 are key in controlling stem cell numbers in psoriasis.
January 2007 in “Queen Mary Research Online (Queen Mary University of London)” GLI and EGF signalling affect Basal Cell Carcinoma development and could be therapeutic targets.
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March 2010 in “PloS one” C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
September 2003 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” GLABRA2 gene controls root-hair growth by regulating phospholipid signaling.
November 2011 in “Molecular Cancer Therapeutics” The Hedgehog signaling pathway is linked to cancer development, and targeting it with inhibitors shows promise but faces challenges like resistance.
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December 2004 in “Proceedings of the National Academy of Sciences” BMP signaling affects hair color by interacting with the MC-1R pathway.
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March 2020 in “American Journal of Medical Genetics Part A” A mutation in the EDNRA gene causes Oro-Oto-Cardiac syndrome, affecting face and heart development.
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January 2018 Sphingosine 1-phosphate and its receptor S1PR3 are key in controlling mechanical pain.
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December 2013 in “Stem cells and development” Horse skin stem cells combined with platelet-rich plasma improve skin healing.
December 2021 in “Figshare” BBS7 is crucial for maintaining healthy gums through Shh signaling.
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September 2025 in “Journal of Clinical Medicine” Small extracellular vesicles can help diagnose and manage sepsis.
August 2016 in “Journal of Investigative Dermatology” The endocannabinoid system affects oil production and inflammation in skin cells.
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June 2004 in “Työväentutkimus Vuosikirja” Ectodermal dysplasia syndromes are caused by disruptions in key signaling pathways affecting tooth and hair development.
April 2026 in “Current Opinion in Genetics & Development” RNA is crucial for controlling cell flexibility and regeneration.
April 2021 in “Journal of Investigative Dermatology” Bacteria can help skin regenerate through a process called IL-1β signaling.
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January 2002 in “Skin Pharmacology and Physiology” Reconstructed skin models are useful for studying how skin processes certain chemicals.
June 2020 in “Journal of Investigative Dermatology” Atopic dermatitis shows a link between skin layers in inflammation, detectable with detailed gene analysis.
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March 2018 in “International Journal of Molecular Sciences” The extracellular matrix is crucial for controlling skin stem cell behavior and health.
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May 2018 in “EMBO journal” Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.
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January 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” PrrH sRNA controls pyochelin gene expression in Pseudomonas aeruginosa based on heme levels.
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September 2004 in “Development” Proper hedgehog signaling is crucial for maintaining healthy skin stem cells.
September 2017 in “Journal of Investigative Dermatology” Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.
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November 2023 in “International Journal of Molecular Sciences” SOX18 helps sheep hair cells grow by activating a specific cell growth pathway.
December 2021 in “Figshare” BBS7 is essential for maintaining healthy gums and teeth.
February 2023 in “International Journal of Molecular Sciences” Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
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June 2023 in “Cell Reports” IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.