January 2011 in “Reactions Weekly” St. John's Wort may reduce the effectiveness of finasteride by increasing its breakdown in the body.
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April 2010 in “Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology” The piRNA pathway genes are crucial in early development and may influence sex differentiation through hormone regulation.
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May 2002 in “PubMed” LGD1069 effectively prevents breast tumors in mice without toxicity.
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January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.
January 2014 in “Side effects of drugs annual” Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.
8 citations
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December 2003 in “Experimental Dermatology” Altering the keratin 17 gene in mice hair follicles caused temporary hair issues, but changes were minimal and short-lived.
January 2002 in “NCSU Libraries Repository (North Carolina State University Libraries)” 17b-Estradiol in skin affects hair growth and tumor promotion.
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September 2010 in “Stress” Neurosteroids help protect fetal brains from asphyxia damage.
Ethanol changes GABAA receptor α4 subunit levels through phosphorylation and neuroactive steroids.
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September 1971 in “Metabolism, clinical and experimental” Dihydrotestosterone has a reduced effect on muscle-building in people with testicular feminization syndrome, especially after their gonads are removed.
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October 2016 in “Clinics in dermatology” Sex hormones, especially androgens, play a key role in causing acne.
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December 1996 in “Fertility and Sterility” Women with acne have lower levels of a specific hormone marker than women without acne.
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May 2010 in “Journal of Cellular Physiology” Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
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November 1982 in “British journal of dermatology/British journal of dermatology, Supplement” Testosterone and some of its forms can strongly stimulate oil gland growth in skin.
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March 2003 in “Journal of Investigative Dermatology” 17β-estradiol can reduce inflammation in the skin.
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June 1989 in “Steroids” Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
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October 2011 in “ISRN Ophthalmology” Higher testosterone and dehydroepiandrosterone sulphate levels may help diagnose meibomian gland dysfunction.
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December 1988 in “Journal of Biochemical Toxicology” TCDD reduces EGF receptors in the liver, affecting growth and development.
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February 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
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March 2014 in “Journal of Pharmacological and Toxicological Methods” The animal models successfully simulated dry eye related to sex steroid deficiency.
A stable sheep ovarian cell line was created for studying reproduction and hormones.
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January 1989 Testosterone and dihydrotestosterone slow hair cell growth, while estradiol has no effect.
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May 1986 in “Clinics in endocrinology and metabolism” Androstanediol glucuronide is a reliable marker for hirsutism in women.
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July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology” The new compounds may be more effective and cheaper than current treatments for conditions like baldness.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” Steroid-producing capabilities in certain cancers may contribute to treatment resistance.
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May 2001 in “Proceedings of the National Academy of Sciences” Overexpression of COX-2 in mice skin causes abnormal skin and hair development.
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September 2021 in “Journal of Neuroendocrinology” Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.
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March 1997 in “Journal of Investigative Dermatology”
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August 1952 in “The Journal of Clinical Endocrinology & Metabolism” A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.
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April 2017 in “Journal of Investigative Dermatology” Topical glucocorticoids thin the skin and change collagen structure.