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GlossaryExtracellular Matrix Organization

network of proteins and molecules outside cells is structured

Extracellular Matrix Organization (ECM Organization) refers to the process by which the network of proteins and other molecules outside cells is structured and maintained. This matrix provides structural support to tissues, influences cell behavior, and plays a crucial role in wound healing, tissue repair, and overall cellular function. Proper ECM organization is essential for maintaining healthy skin and hair, and disruptions in this process can contribute to conditions like alopecia.

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research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization

research O19 CYLD cutaneous syndrome tumours demonstrate increased NF-κB signalling and diminished collagen organisation.

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.

Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device

research Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device

March 2024 in “Advanced healthcare materials/Advanced Healthcare Materials”

Scientists developed a new way to create skin-like structures from stem cells using a special 3D gel and a device that improves cell organization and increases hair growth.

research Comparative transcriptomic analysis of human mesenchymal stem cells derived from dental pulp and adipose tissues

8 citations , May 2019 in “Journal of Stem Cells & Regenerative Medicine”

Dental pulp stem cells are better for tissue repair, while fat tissue stem cells may be more suited for wound healing and hair growth.

research ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes

4 citations , May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

ELL is crucial for gene transcription related to skin cell growth.

Detecting the Mechanism Behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus Nippon) Dermal Papilla Cells to Three-Dimensional Pattern

research Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus nippon) Dermal Papilla Cells to Three-Dimensional Pattern

2 citations , April 2021 in “International Journal of Molecular Sciences”

The study concluded that changing the culture conditions can cause sika deer skin cells to switch from a flat to a 3D pattern, which is important for creating hair follicles.

research 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa

November 2024 in “Journal of Investigative Dermatology”

Scalp hair follicle cells help protect and heal skin in certain skin conditions.

research SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

87 citations , September 2019 in “Nature Communications”

SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.

research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

97 citations , May 2019 in “Frontiers in Cell and Developmental Biology”

Abnormal ECM and immune cell interactions can cause skin diseases.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

research 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin

November 2025 in “Journal of Investigative Dermatology”

Dark skin has stronger barriers and structure due to specific gene activity.

research EVALUATION OF EFFICACY OF FOLLICULAR UNIT EXCISION VERSUS FOLLICULAR UNIT EXCISION WITH NANOFAT IN SCARS IN HAIRY AREAS

April 2025 in “ALEXMED ePosters”

Combining nanofat with FUE improves scar appearance and function better than FUE alone.

research 707 Guiding skin organoid generation via extracellular matrix cues and spatially controlled morphogen gradients

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists improved how to make skin-like structures from stem cells using special gels and a device that controls growth signals, leading to better hair and skin features.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research Progenitor Cell Dynamics in Androgenetic Alopecia: Insights from Spatially Resolved Transcriptomics

June 2025 in “International Journal of Molecular Sciences”

Targeting EMT and fibrotic remodeling may help treat androgenetic alopecia.

research Hardwiring Stem Cell Communication through Tissue Structure

82 citations , March 2016 in “Cell”

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

research 1270 Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

3 citations , April 2018 in “Journal of Investigative Dermatology”

CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.

research Identification of key genes in type 2 diabetes‐induced erectile dysfunction rats with stem cell therapy through high‐throughput sequencing and bioinformatic analysis

2 citations , March 2021 in “Andrologia”

Stem cell therapy affects 15 key genes in rats with diabetes-related erectile dysfunction.

research Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

2 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.

research Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development

January 2023 in “Biomaterials Science”

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

research Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

25 citations , April 2021 in “The EMBO Journal”

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

Basement Membrane Components Define the Microenvironment of Aggregated Fibroblasts in the Skin and Support Their Aggregation In Vitro

research Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro

September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Basement membrane supports fibroblast aggregation, aiding hair follicle development.

High-Throughput Screening of 3D Co-Culture Hair Follicle Mimetic Tissue with Enhanced ECM for the Screening of Hair Growth Promoting Compounds

research High-throughput screening of 3D co-culture hair follicle mimetic tissue with enhanced ECM for the screening of hair growth promoting compounds

January 2024 in “Biomaterials Research”

The new 3D system helps test hair growth treatments effectively.

research 1456 Tensor effect of anigozanthos flavidus flower extract: Modulation of tenascin-X to regenerate the skin

April 2018 in “Journal of Investigative Dermatology”

Anigozanthos Flavidus flower extract helps regenerate skin and reduce wrinkles.

research Comparative Skin Transcriptomics Reveals Key Regulators of Cashmere Fiber Production in Inner Mongolian Goats

March 2026 in “Animals”

Key genes and pathways influence cashmere production in goats.

research Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models

21 citations , December 2023 in “Bioengineering & Translational Medicine”

Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

November 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

The dataset includes detailed genetic information from mouse skin cells before and after injury.

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

November 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

The dataset includes detailed genetic information from mouse skin cells before and after injury.

The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.