March 2024 in “Jagiellonian University Repository (Jagiellonian University)” Genetic and lifestyle factors influence skin and hair aging, and prediction models can help assess aging and cosmetic treatments.
July 2020 in “RePub (Erasmus University, Rotterdam)” Facial skin aging is influenced by wrinkles, spots, genetics, and environment.
July 2024 in “Journal of Investigative Dermatology” Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.
April 2023 in “Journal of Investigative Dermatology” Scientists created a 3D skin model that shows typical signs of aging, which can help in aging research.
2 citations
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February 2021 in “Developmental Cell” Middle-aged skin shows aging signs, and quercetin might help delay them.
November 2022 in “Journal of Investigative Dermatology” Aging in one type of stem cell can cause aging-like changes in various organs.
January 2019 in “Elsevier eBooks” Skin aging helps us understand overall aging.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Aging causes changes in scalp cells that can negatively affect hair health.
2 citations
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September 2019 in “Current Issues in Pharmacy and Medical Sciences” Changing habits can make you look younger and improve your overall health.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Aged individuals heal wounds less effectively due to specific immune cell issues.
3 citations
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February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY” Certain genes are linked to skin aging, like wrinkles and pigmentation changes.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” Red light exposure can slow aging in mice by improving fat metabolism.
This study demonstrates that periodic exposure to red light can mitigate aging in mice by enhancing histone H3 Lys9 acetylation (H3K9ac) through the modulation of fatty acid metabolism. Red light exposure reduces SIRT4 protein levels in keratinocytes, which activates glycolysis, fatty acid metabolism, and the TCA cycle. The decrease in SIRT4 enhances mitochondrial fatty acid oxidation and activates SIRT1, which in turn activates PPAR-α, leading to increased expression of lipid metabolism-related genes. This results in the accumulation of acetyl-CoA, increased H3K9ac levels, and altered expression of senescence-related genes, effectively reducing cellular aging through coordinated regulation of metabolism, inflammation, and gene expression.
March 2026 in “BioScience Trends” UV radiation causes skin aging by damaging cells and triggering harmful processes.
January 1974 in “OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)” Oxidative stress causes hair graying by damaging hair follicle melanocytes more than skin melanocytes.
November 2022 in “Journal of Investigative Dermatology” Aging skin cells change their lipid profiles due to stress, affecting skin health.
This study demonstrates that periodic exposure to red light can mitigate aging in mice by enhancing histone H3 Lys9 acetylation (H3K9ac) through the modulation of fatty acid metabolism. Red light exposure reduces SIRT4 protein levels in keratinocytes, which activates glycolysis, fatty acid metabolism, and the TCA cycle. The decrease in SIRT4 enhances mitochondrial fatty acid oxidation and activates SIRT1, which in turn alleviates inhibition on PPAR-α, leading to increased expression of lipid metabolism-related genes. This results in the accumulation of acetyl-CoA, increased H3K9ac levels, and altered expression of senescence-related genes, effectively reducing cellular aging through coordinated regulation of metabolism, inflammation, and gene expression.
Aging disrupts skin repair and stress responses, but exercise-related IL-15 improves wound healing and skin health in older skin.
3 citations
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August 2021 in “Research Square (Research Square)” The most common sign of aging at the gene level is more Ectodysplasin A2 Receptor (EDA2R) being made.
April 2023 in “Journal of Investigative Dermatology” Urban pollution and sun exposure speed up skin aging and wrinkle formation in Chinese women, with pollution's effects becoming significant after age 45.
December 1989 in “PubMed” June 2023 in “Skin Health and Disease” 7 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” Epigenetic and metabolic changes affect stem cell function and aging in skin.
April 2017 in “Our Dermatology Online” Using cosmetics made elderly people feel more comfortable and attractive.
2 citations
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September 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” Self-perceived facial aging is linked to skin pigmentation, immune system, hair loss in men, and genes related to the skin's structure.
September 2017 in “Journal of Investigative Dermatology” Aging causes sweat glands to shrink and move upward, leading to less elastic skin and more wrinkles.
1 citations
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January 2025 in “Aging and Disease” Lengthening telomeres may reverse aging and extend lifespan.
November 2005 in “Physiology” Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.
April 2015 in “Experimental Dermatology” Melanoma risk tools need improvement, certain gene mutations cause skin diseases and could be treated by targeting those mutations, skin wrinkling may relate to lung aging due to genetic factors, and oxidative stress affects hair loss but can be reduced in low oxygen.
1 citations
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October 2025 in “Experimental Dermatology” Mast cells influence skin aging and are potential targets for anti-aging treatments.