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High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.

Hormone therapies improve mental health and quality of life for those with gender dysphoria.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Gender-affirming hormone therapy may increase heart disease risk in transgender individuals.

Blocking androgens at birth reduces sexual motivation in male rats.

Cyproterone slightly inhibited hair growth in castrated mice, while tamoxifen significantly inhibited hair growth in castrated mice but not in normal mice.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Gender-affirming hormone therapy and surgery affect gut bacteria differently.

A transman experienced lasting virilization symptoms after stopping testosterone, which were resolved with estradiol treatment.

Inhibiting 5α-reductase during late pregnancy shortens gestation, reduces litter size, and harms memory in rat offspring.

Finasteride slows down motherly behavior in first-time pregnant rats.

Testosterone undecanoate increases lean mass and causes various physical changes in female-to-male transsexuals.

Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.

Masculinization in affected individuals occurs gradually after puberty due to hormone changes.

Finasteride affects prostate development differently in male and female Mongolian gerbils.

Facial feminization surgery is safe and patients are satisfied, but more detailed research is needed.

More research is needed to improve lower body gender affirmation techniques.

Blocking progesterone metabolism can cause depression-like behavior in mice.

Treatment during development affects hormone balance and sexual behavior in male rats.

Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.

Gender-affirming dermatology treatments generally improve mental well-being for transgender individuals, but more research is needed.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Testosterone significantly affects urination differences between male and female mice.

Facial feminization surgery helps make facial features more feminine, improving patient satisfaction and safety.

Finasteride effectively treats hair loss in transgender men with few side effects.

Individuals with this condition often develop male traits and identities at puberty despite being raised as females.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.