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Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

Sebum production varies by individual and is influenced by age, gender, and hormones, affecting skin and hair health.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

AGA treatments like minoxidil and LLLLT are safe and effective for gender minority patients.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Gender affirming hormone therapy improves outcomes in gender affirmation surgery.

Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.

Female pattern hair loss has multiple causes and treatments, with new therapies showing promise.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

Clascoterone cream effectively reduces acne severity and is safe for patients 12 and older.

Improved access to hair removal is crucial for transgender individuals before feminizing surgeries.

A man with a rare adrenal cancer showed unusual symptoms and died four months after diagnosis.

A man's rare adrenal tumor caused feminization and white hair, was removed surgically, and improved after treatment.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Gender-affirming hormone therapy affects health risks and requires careful management, especially as transgender individuals age.

Transgender women can develop feminine traits and improve their quality of life through hormone therapy and surgery, but results vary and access to surgery can be limited.

Transgender and nonbinary individuals experience hair loss, with transmen on testosterone seeing more severe hair loss, while feminizing hormones may stabilize hair loss in transwomen.

Hormone therapy may increase migraines in transgender women and decrease them in transgender men; more research is needed on migraine management in transgender individuals.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The document concludes that respectful, gender-affirming healthcare improves mental health and encourages continued medical care for transgender and non-binary individuals.

Transgender youth on hormone therapy need personalized acne treatments and supportive care.

Transgender acne treatment requires a tailored approach with ongoing topical treatments and ceramide-rich moisturizers.

Feminizing hormone therapy increases kidney filtration rate.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Most transgender patients getting laser hair removal before gender-affirming surgery are already on hormone therapy, which might affect the hair removal process.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Transgender patients on masculinizing hormones have higher hair loss rates than cisgender women.

Transgender patients on hormone therapy experience more acne and hair loss, but less skin inflammation.

Many children and teens referred to gender services receive hormone treatments, but more research is needed on their long-term care and outcomes.