October 2024 in “Journal of Cosmetic Dermatology” Over half of young people in Saudi Arabia experience early gray hair, linked to factors like smoking, stress, and family history.
October 2022 in “IntechOpen eBooks” Hair loss due to scarring can be treated by reducing inflammation, removing scar tissue, and transplanting hair. The Follicular Unit Extraction technique is effective but requires skill and time. Future focus should be on scar-less healing methods.
April 2008 in “Experimental Dermatology” Early surgery and quitting smoking can help manage hidradenitis suppurativa.
79 citations
,
January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology” Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
56 citations
,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
50 citations
,
August 2021 in “Stem Cell Research & Therapy” Adipose-derived stem cells help heal radiation skin damage by reducing cell death and inflammation.
49 citations
,
November 2021 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
47 citations
,
June 2013 in “Biology of blood and marrow transplantation” Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.
44 citations
,
June 2023 in “Cell Reports” IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
35 citations
,
February 2023 in “Journal of Clinical Medicine” Demodex mites are common in adults and elderly, emerging in children, and require careful diagnosis and treatment.
35 citations
,
October 2014 in “Wound Repair and Regeneration” The model helps understand scar contraction and develop new treatments.
20 citations
,
August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.
20 citations
,
November 2020 in “Stem Cell Research & Therapy” Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.
10 citations
,
May 2025 in “Nutrition & Metabolism” Metabolic syndrome is linked to skin diseases, requiring integrated treatment and monitoring.
9 citations
,
June 2023 in “Human Genomics” MX1 and AR genes are linked to milder COVID-19, while TMPRSS2 increases severe risk, especially in women.
8 citations
,
August 2025 in “Journal of Translational Medicine” CD44 signaling can help heal wounds without scars.
7 citations
,
August 2023 in “Frontiers in Immunology” Targeting TRP channels may help reduce excessive scarring.
4 citations
,
December 2024 in “European Journal of Medicinal Chemistry” New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.
4 citations
,
January 2018 in “Journal of dermatology & dermatologic surgery” There is no gold standard treatment for hidradenitis suppurativa due to insufficient evidence.
3 citations
,
February 2025 in “Frontiers in Cell and Developmental Biology” Wharton's Jelly stem cell medium may help treat skin issues in Systemic Sclerosis.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” COVID-19 can cause hair loss, and treatments like PRP and stem cells might help.
3 citations
,
January 2021 in “Medicinski arhiv” Trichoscopy, a hair loss evaluation technique, found that people with Androgenetic Alopecia have more thin hairs, yellow dots, and perifollicular discoloration than healthy individuals.
2 citations
,
April 2025 in “Journal of Investigative Dermatology” T cells affect skin cell genes in inflammatory diseases, and therapy can normalize these changes.
2 citations
,
October 2021 in “JID innovations” Uterine leiomyomas don't significantly change gene expression in the scalp of people with Central Centrifugal Cicatricial Alopecia.
1 citations
,
October 2025 in “Frontiers in Cardiovascular Medicine” Anabolic-androgenic steroid abuse can cause heart damage and sudden death.
1 citations
,
November 2024 in “Blood” PI3Kδ inhibition may effectively treat cutaneous chronic graft-versus-host disease.
1 citations
,
January 2024 in “Fibrosis” Hydrogels show promise for scarless wound healing by reducing skin fibrosis.
1 citations
,
July 2021 in “Journal of Skin and Sexually Transmitted Diseases” Lipedema is a painful fat disorder in women that's hard to treat, often worsens with hormonal changes, and requires symptom-focused therapies.
February 2026 in “International Journal of Molecular Sciences” Targeting mitochondria can improve skin healing and rejuvenation.
February 2026 in “Advanced Science” Targeting the p300/AR axis may help treat polycystic ovary syndrome.