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GlossaryFollicle Depth

distance from skin surface to hair follicle base

Follicle depth refers to the distance from the surface of the skin to the base of the hair follicle, where hair growth begins. This measurement is important for understanding hair growth patterns, diagnosing conditions like alopecia, and planning treatments such as hair transplants.

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A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

research A systematic summary of survival and death signalling during the life of hair follicle stem cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

research Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

2 citations , January 2019 in “Indian Journal of Pharmaceutical Sciences”

Zinc chloride can cause human scalp cells to multiply and die.

research 1391 Cell death functions in hair follicle regeneration

April 2023 in “Journal of Investigative Dermatology”

Proper cell death regulation is crucial for normal hair follicle regeneration and skin remodeling.

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo andIn Vitro

140 citations , December 1998 in “Journal of Investigative Dermatology”

Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.

research Apoptotic cell death in canine hair follicle.

5 citations , January 2005 in “PubMed”

Apoptosis is important in the hair cycle of dogs.

research ISID1391 – Cell death functions in hair follicle regeneration

May 2023

research Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin

36 citations , July 2004 in “Journal of Controlled Release”

The dye quickly penetrates hair follicles, mainly through the gap, not the surrounding skin.

research ISID1373 - Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

April 2023

Higher PD-1 levels mean fewer CD8+ T cells in alopecia areata hair follicles.

Expression of Programmed Cell Death 1 Inversely Correlated With the Density of CD8+ T Cells Infiltrating Hair Follicles in Alopecia Areata

research 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

Higher PD-1 levels are linked to fewer immune cells in hair follicles in alopecia areata.

research Apoptotic cells may drive cell death in hair follicles during their regression cycle

October 2023 in “Oncotarget”

Apoptotic cells help cause hair follicle cell death during regression.

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

2 citations , April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research Apoptotic Cells May Drive Cell Death in Hair Follicles During their Regression Cycle

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Apoptotic cells may trigger cell death in hair follicles during their regression cycle.

research VDR is an essential regulator of hair follicle regression through the progression of cell death

1 citations , September 2023 in “Life science alliance”

Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.

research Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells.

July 2024 in “PubMed”

Hypoxic preconditioning helps human hair follicle stem cells survive oxidative stress.

Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

research Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles

12 citations , December 2019 in “International Journal of Molecular Medicine”

Stem cells from umbilical cord blood may prevent hair loss caused by certain medications.

research Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

30 citations , May 2016 in “International Journal of Cosmetic Science”

Hair loss in women links to inflammation around hair follicles.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

25 citations , September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

research Ultrasonography In Hair Follicle Pathology

November 2014 in “ACTUALIDAD MEDICA”

Ultrasonography can help diagnose and monitor hair loss conditions.

research 699 Effect of Prostaglandin D 2 on hair follicle growth and its impact on hair follicle stem/progenitor cells

1 citations , April 2016 in “Journal of Investigative Dermatology”

Blocking Prostaglandin D₂ may help treat hair loss.

research The Hair Follicle as a Dynamic Miniorgan

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations , April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research BMP signaling in the control of skin development and hair follicle growth

165 citations , December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research Human hair follicle organ culture: theory, application and perspectives

130 citations , August 2015 in “Experimental Dermatology”

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

research Do Hair Bulb Melanocytes Undergo Apotosis During Hair Follicle Regression (Catagen)?

130 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.

Cell Death in the Skin: Mechanisms and Implications

research Cell death in the skin

120 citations , February 2009 in “Apoptosis”

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.