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GlossaryFractional Lasers

target small skin areas to boost collagen and rejuvenation

Fractional lasers, also known as fractional laser therapy or fractional laser resurfacing, are a type of laser treatment that targets small, precise areas of the skin to promote collagen production and skin rejuvenation. By creating microscopic columns of treated skin surrounded by untreated tissue, these lasers help in faster healing and are commonly used for reducing wrinkles, scars, and pigmentation issues.

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research Synergistic Effects of Fractional CO ₂ Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

January 2025 in “Dermatologic Therapy”

Combining fractional CO₂ laser with type III collagen improves acne scar treatment.

Research Progress on Fractional CO2 Laser in Multimodal Therapy

research Research Progress on Fractional CO₂ Laser in Multimodal Therapy

January 2025 in “Advances in Clinical Medicine”

Fractional CO2 laser therapy effectively improves skin conditions and recovery when combined with other treatments.

research Contraindications of Using Fractional CO₂ Laser in the Treatment of Aesthetic Disorders: A Narrative Review

January 2025 in “Journal of Biosciences and Medicines”

Careful patient selection is crucial for safe and effective fractional CO2 laser therapy.

$Successful Response to a Combination of Intralesional Methotrexate and Fractional CO2 Laser in Refractory Alopecia Areata: Case Report$

research Successful Response to a Combination of Intralesional Methotrexate and Fractional CO₂ Laser in Refractory Alopecia Areata: Case Report

2 citations , January 2022 in “Skin appendage disorders”

A combination of methotrexate injections and CO2 laser treatment led to complete hair regrowth in two patients with hard-to-treat alopecia.

research The Efficacy and Safety of Ablative Fractional CO ₂ Laser Combined With Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial

January 2026 in “Dermatologic Therapy”

Combining laser treatment with minoxidil is more effective for hair growth in men than using minoxidil alone.

research Efficacy and Safety of Ablative Fractional CO ₂ Laser Therapy for Localized Scleroderma: A Comprehensive Bench‐to‐Bedside Approach

January 2025 in “Dermatologic Therapy”

CO₂ laser therapy improves skin and hair growth in localized scleroderma without severe side effects.

Faculty Opinions Recommendation of Treatment of Alopecia Areata with Nonablative Fractional Laser Combined with Topical Minoxidil

research Faculty Opinions recommendation of Treatment of alopecia areata with nonablative fractional laser combined with topical minoxidil.

March 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Combining nonablative fractional laser with minoxidil was effective for alopecia areata with only one patient relapsing after a year.

research Expression of collagen type I, skin fibroblasts and macrophages after 1550 nm erbium glass fractional laser in androgenic alopecia

January 2020

The 1550 nm fractional Er:Glass laser improved hair regrowth in patients with androgenic alopecia, but didn't significantly change collagen type I, skin fibroblasts, or macrophages. More research is needed for optimal results.

research Enhancing hair growth in male androgenetic alopecia by a combination of fractional CO2 laser therapy and hair growth factors

26 citations , May 2017 in “Lasers in Medical Science”

Laser therapy and hair growth factors significantly improve hair density in male baldness.

Comparative Study Between Ablative Fractional Carbon Dioxide Laser Combined With Topical Steroid Versus Topical Steroid in Treatment of Alopecia Areata

research Comparative Study Between Ablative Fractional Carbon Dioxide Laser Combined with Topical Steroid Versus Topical Steroid in Treatment of Alopecia Areata

October 2025 in “Iraqi postgraduate medical journal”

Combining laser treatment with steroid cream is more effective for alopecia areata than using the cream alone.

research Current Status of Fractional Laser Resurfacing

44 citations , July 2015 in “JAMA Facial Plastic Surgery”

Fractional laser resurfacing is effective and safe for skin treatment, with benefits like less downtime and a low risk of adverse events.

research Histologic comparison of microscopic treatment zones induced by fractional lasers and radiofrequency

27 citations , August 2014 in “Journal of Cosmetic and Laser Therapy”

Different lasers and radiofrequency affect skin differently, important for dermatologists to choose the right treatment.

research Study on different fractional CO2 laser parameters combined with halometasone in treatment of chronic eczema

2 citations , April 2025 in “Lasers in Medical Science”

Combining fractional CO2 laser with halometasone cream is more effective for chronic eczema than the cream alone.

research Fractional Photothermolysis Laser Treatment of Male Pattern Hair Loss

50 citations , December 2010 in “Dermatologic Surgery”

Laser treatment can stimulate hair growth for male pattern hair loss.

research Treatment of alopecia areata with nonablative fractional laser combined with topical minoxidil

8 citations , June 2019 in “Journal of Cosmetic Dermatology”

Using a nonablative fractional laser with topical minoxidil can effectively and safely promote hair regrowth in alopecia areata patients.

research Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review

7 citations , June 2019 in “Cureus”

Fractional lasers and microneedling, combined with topical agents, could potentially treat Alopecia Areata effectively, but more research is needed due to limited data.

research Fractional non-ablative laser-assisted drug delivery leads to improvement in male and female pattern hair loss

15 citations , February 2018 in “Journal of Cosmetic and Laser Therapy”

Laser-assisted drug delivery improves hair loss.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

The Efficacy of 1550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research 411 The efficacy of 1550-nm erbium-glass fractional laser treatment and its effect on the expression of insulin-like growth factor 1 and Wnt/β-catenin in androgenetic alopecia

April 2018 in “Journal of Investigative Dermatology”

Finasteride helps female-pattern hair loss.

research Adverse events of non-ablative fractional laser photothermolysis: a retrospective study of 856 treatments in 362 patients

18 citations , May 2013 in “Journal of Dermatological Treatment”

Non-ablative fractional laser treatments have a low risk of side effects in Asian patients.

research The effect of a 1550 nm fractional erbium-glass laser in female pattern hair loss

47 citations , August 2011 in “Journal of The European Academy of Dermatology and Venereology”

Laser treatment increases hair density and thickness safely in women with hair loss.

research Hair regrowth through wound healing process after ablative fractional laser treatment in a murine model

26 citations , May 2015 in “Lasers in Surgery and Medicine”

Laser treatment helped regrow hair in mice by activating a key growth pathway.

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

10 citations , August 2018 in “Dermatologic Surgery”

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.

Alterations of Collagen Type 1, Skin Fibroblasts, and Macrophages in the Scalp Following the Treatment of 1550-nm Erbium Glass Fractional Laser for Androgenetic Alopecia

research Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia

June 2021 in “Journal of Cosmetic Dermatology”

Laser treatment shows promise for hair growth, but needs further research.

The Role of Fractional Laser-Assisted Drug Delivery in Enhancing the Efficacy of Topical Bimatoprost Solution in the Treatment of Alopecia Areata: An Intra-Patient Comparative Randomized Clinical Trial

research The role of fractional laser‐assisted drug delivery in enhancing the efficacy of topical bimatoprost solution in the treatment of alopecia areata: An intra‐patient comparative randomized clinical trial

February 2024 in “Journal of Cosmetic Dermatology”

Using a laser with bimatoprost solution works better for hair regrowth in alopecia areata than bimatoprost alone.

research Hair Loss Treatment Using Erbium:YAG Fractional Laser with Hair Growth-promoting Solution

September 2021 in “Medical lasers”

Laser treatment followed by a special hair growth solution increased hair count and thickness without side effects.

Combination of a Non-Ablative 1,927 nm Thulium Fiber Fractional Laser and Autologous Platelet-Rich Plasma in Treatment of Male Androgenetic Alopecia: A Pilot Study

research Combination of a non-ablative 1,927 nm thulium fiber fractional laser and autologous platelet-rich plasma in treatment of male androgenetic alopecia: A pilot study

January 2019 in “Chulalongkorn Medical Journal”

Using a special laser and platelet-rich plasma together is safe and improves hair growth in men with hair loss.

research Fractional resurfacing in the Asian patient: Current state of the art

33 citations , September 2016 in “Lasers in Surgery and Medicine”

Fractional resurfacing is safe and effective for certain skin conditions in Asian patients, but care must be taken to avoid skin pigmentation issues.

Efficacy and Safety of Fractional CO2 Laser Combined with Halometasone Cream for Treatment of Moderate-to-Severe Chronic Hand Eczema: A Prospective, Single-Center, Parallel-Group, Open-Label Randomized Trial

research Efficacy and Safety of Fractional CO2 Laser Combined with Halometasone Cream for Treatment of Moderate-to-Severe Chronic Hand Eczema: A Prospective, Single-Center, Parallel-Group, Open-Label Randomized Trial

June 2023 in “Dermatology and Therapy”

Using fractional CO2 laser with halometasone cream works better for chronic hand eczema than just the cream, improving symptoms and quality of life with fewer relapses.

research Fractional CO2 laser, platelet rich plasma and combination of both in treatment of female pattern hair loss

May 2024 in “Journal of the Egyptian Women's Dermatologic Society /Journal of the Egyptian Women's Dermatologic Society”

Combining fractional CO2 laser and PRP is very effective for treating female hair loss.