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GlossaryGene Ontology

standardized system categorizing gene functions across species

Gene Ontology (GO) is a comprehensive framework that organizes information about gene functions across different species. It categorizes genes into three main aspects: biological processes (what the gene product does), cellular components (where the gene product is active), and molecular functions (how the gene product acts). This standardized vocabulary helps researchers understand gene roles and interactions, facilitating cross-species comparisons and enhancing biological research.

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research Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

16 citations , December 2020 in “PloS one”

Researchers found WNT10A to be a key gene in developing goat hair follicles.

research Differential gene expression profiles in foetal skin of Rex rabbits with different wool density

4 citations , September 2016 in “World Rabbit Science”

High wool density in Rex rabbits is linked to specific gene activity affecting hair follicle development.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.

research Urological Oncology: Prostate Cancer

August 2010 in “The Journal of urology/The journal of urology”

Male pattern baldness may be linked to prostate cancer risk.

research MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes

2 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

New Developments in Stem Cell Biology and Therapy: Meeting Report from the Working Group of the German Society for Hematology and Oncology

research New developments in stem cell biology and therapy. meeting report from the working group of the German Society for Hematology and Oncology

5 citations , January 2005 in “Cytotherapy”

The meeting highlighted important advances in stem cell research and its potential for creating new medical treatments.

Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

26 citations , April 2019 in “Genes”

lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

research Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells

12 citations , April 2014 in “Molecular Medicine Reports”

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

research Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low‐volume, high‐intensity interval training

10 citations , December 2017 in “Physiological Reports”

Hair follicle analysis can track body changes from high-intensity interval training.

research Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape

8 citations , July 2020 in “BMC genomics”

The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

8 citations , March 2023 in “International Wound Journal”

IGF2BP3 and other m6A-related genes are linked to keloid formation and could be potential treatment targets.

research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment

7 citations , December 2019 in “Experimental and Therapeutic Medicine”

WNT10B affects hair growth by altering gene activity in hair cells.

research RNA sequence analysis of dermal papilla cells’ regeneration in 3D culture

6 citations , October 2020 in “Journal of Cellular and Molecular Medicine”

3D culture helps maintain hair growth cells better than 2D culture and identifies key genes for potential hair loss treatments.

research Computational Drug Discovery in Chemotherapy-induced Alopecia via Text Mining and Biomedical Databases

3 citations , April 2019 in “Clinical Therapeutics”

Computational tools identified 29 drugs that could potentially target 19 genes involved in chemotherapy-induced hair loss, which could lead to more effective treatments.

research Combining multiomics to analyze the molecular mechanism of hair follicle cycle change in cashmere goats from Inner Mongolia

2 citations , July 2024 in “Frontiers in Veterinary Science”

Apoptosis and ribosomal proteins are key in hair follicle cycle changes in cashmere goats.

Proteomics-Based Screening of Differentially Expressed Proteins in Skin of Chinese Merino Fine Sheep (JunKen Type) by Gender

research [Proteomics-based screening of differentially expressed proteins in skin of Chinese merino fine sheep (JunKen type) of different gender].

1 citations , October 2022 in “PubMed”

Gender affects wool traits in sheep, with males and females showing differences in skin proteins related to wool growth.

research Identification and profiling of microRNA between back and belly Skin in Rex rabbits (Oryctolagus cuniculus)

1 citations , June 2018 in “World rabbit science”

Different miRNAs in Rex rabbit skin affect cell processes and hair growth.

research Association Between Androgenic Alopecia and Schizophrenia: A Bidirectional Mendelian Randomization Study

April 2025 in “International Journal of Dermatology and Venereology”

Androgenetic alopecia may cause schizophrenia, but schizophrenia does not cause androgenetic alopecia.

research Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep

November 2023

Researchers found genes in sheep that may affect hair growth and wool quality.

research Analysis of histology and long noncoding RNAs involved in the rabbit hair follicle density using RNA sequencing

January 2021 in “Research Square (Research Square)”

Rabbits with high wool production have more hair follicles, influenced by specific long noncoding RNAs.

research SF-066-4 線維芽細胞+血管内皮前駆細胞共培養シートを用いた新たな膵断端処理法の開発(膵-2,サージカルフォーラム,第110回日本外科学会定期学術集会)

March 2010 in “日本外科学会雑誌”

Metabolic processes and key genes like FGF5, FGFR1, and RRAS significantly affect hair follicle growth in Inner Mongolian Cashmere goats.

Analysis of Histology and Long Noncoding RNAs Involved in Rabbit Hair Follicle Density Using RNA Sequencing

research Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density using RNA Sequencing

September 2020 in “Research Square (Research Square)”

Long noncoding RNAs help regulate hair follicle density in rabbits.

research Vestibular Hair Cell Regeneration and Restoration of Balance Function Induced by Math1 Gene Transfer

129 citations , January 2007 in “Otology & Neurotology”

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Evaluation of Hair Follicles as a Surrogate Tissue for Pharmacodynamic Response in Xenograft Tumors

research Evaluation of hair follicles as a surrogate tissue for pharmacodynamics response in xenograft tumors

January 2012

Hair follicles can be used to quickly assess drug effects in cancer treatment.

research Study of seed hair growth in Populus tomentosa, an important character of female floral bud development

20 citations , June 2014 in “BMC genomics”

Poplar seed hairs grow from the placenta at the ovary base, with endoreduplication playing a key role in their development, and share similar cellulose synthesis processes with cotton fibers.

research LncRNAs regulate the cyclic growth and development of hair follicles in Dorper sheep

July 2023 in “Frontiers in veterinary science”

Certain long non-coding RNAs are important for controlling hair growth cycles in sheep.

research Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

February 2021 in “Journal of Investigative Dermatology”

Hair loss in male pattern baldness is linked to changes in specific genes and proteins that affect hair growth and scalp health.

research Editor’s picks January 2021

January 2021 in “Journal of the European Academy of Dermatology and Venereology”

PrEP doesn't increase STI risk in high-risk men, anti-androgen drugs may lower ICU admission for male COVID-19 patients, a 3-point injection is better for crow's feet, and the 'Geriatric-8' tool could help assess frailty in older skin cancer patients.

research QS8: Analysis of the Whole Transcriptome in Breast Cancer Patients Undergoing Radiotherapy and Breast Reconstruction

July 2021 in “Plastic and reconstructive surgery. Global open”

Radiation therapy in breast cancer patients changes gene expression related to DNA damage, fibroblast growth, and hair follicle development, which could help improve treatment for radiation-induced fibrosis.