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GlossaryGene Editing

technique to precisely alter an organism's DNA sequence

Gene editing, also known as genome editing, is a technique that allows scientists to alter an organism's DNA with high precision. This process involves adding, removing, or modifying specific genetic material at particular locations in the genome, often using tools like CRISPR-Cas9. It holds potential for treating genetic disorders, improving crop resilience, and even addressing hair loss conditions like alopecia by targeting and correcting the underlying genetic causes.

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research Progress in Research and Prospects for Application of Precision Gene-Editing Technology Based on CRISPR–Cas9 in the Genetic Improvement of Sheep and Goats

March 2024 in “Agriculture”

CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.

The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

research The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

December 2023

CRISPR/Cas9 gene-editing shows promise for livestock breeding but faces challenges like low efficiency and off-target effects.

Recent Updates of the CRISPR/Cas9 Genome Editing System: Novel Approaches to Regulate Its Spatiotemporal Control by Genetic and Physicochemical Strategies

research Recent Updates of the CRISPR/Cas9 Genome Editing System: Novel Approaches to Regulate Its Spatiotemporal Control by Genetic and Physicochemical Strategies

June 2024 in “International Journal of Nanomedicine”

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

research Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin

6 citations , April 2024 in “Journal of Investigative Dermatology”

CRISPR-based tools improve understanding and treatment of skin development and conditions.

research An induced pluripotent stem cell-based approach for hair follicle development and regeneration

June 2024 in “Regenerative Therapy”

iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.

research CRISPR/Cas9: A Promising Approach for Alopecia

January 2024 in “Biomedical journal of scientific & technical research”

CRISPR/Cas9 gene-editing may effectively treat hair loss but requires more research for safe use.

research Tangled Causes, Targeted Solutions: A Comprehensive Review of Alopecia.

January 2026 in “International Journal of All Research Education & Scientific Methods”

Alopecia is caused by various factors, and new treatments like gene editing and regenerative medicine offer hope for personalized hair regrowth solutions.

research New developments in the molecular treatment of ichthyosis: review of the literature

21 citations , July 2022 in “Orphanet journal of rare diseases”

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

research CRISPR/Cas9-mediated Generation ofCOL7A1-deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa

June 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists created cell lines to study a genetic skin disorder using CRISPR technology.

research Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

104 citations , October 2016 in “PLoS ONE”

CRISPR/Cas9 gene editing in cashmere goats increases hair follicles and fiber length, boosting cashmere yield.

research Generation of a Novel Inducible and Dermal Papilla‐Specific Wif1‐CreER Knock‐In Mouse Line for Hair Follicle Research

May 2025 in “Experimental Dermatology”

A new genetic tool improves the study of hair growth and potential hair disorder treatments.

research Modeling animal genomics in mice: An authentic approach for the functional interrogation of evolutionarily and agriculturally critical variants

1 citations , January 2024 in “Animal Research and One Health”

Mouse models are essential for studying and improving genetic traits in agriculture.

research An infant with congenital micrognathia and upper airway obstruction was diagnosed as Hutchinson-Gilford progeria syndrome caused by a novel LMNA mutation: Case report and literature review

1 citations , October 2023 in “Heliyon”

An infant with Hutchinson-Gilford Progeria Syndrome had successful surgery to fix breathing issues caused by a new genetic mutation.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

research Biomedical applications of organoids in genetic diseases

December 2024 in “Medical Review”

Organoids help study and treat genetic diseases, offering personalized medicine and therapy testing.

research CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing

149 citations , August 2022 in “Biochemistry (Moscow)”

CRISPR-Cas9 allows precise DNA editing but raises ethical concerns about modifying human embryos.

research Spatiotemporal control of CRISPR/Cas9 gene editing

51 citations , June 2021 in “Signal Transduction and Targeted Therapy”

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

research The Current Landscape for Direct-to-Consumer Genetic Testing: Legal, Ethical, and Policy Issues

244 citations , September 2008 in “Annual Review of Genomics and Human Genetics”

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

research Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives

9 citations , August 2024 in “International Journal of Molecular Sciences”

Promising treatments for EBS include anti-inflammatory drugs, antibiotics, creams, mTOR inhibitors, and gene editing, but more trials are needed.

research Review of the Latest Methods of Epidermolysis Bullosa and Other Chronic Wounds Treatment Including BIOOPA Dressing

9 citations , July 2021 in “Dermatology and Therapy”

New treatments for epidermolysis bullosa show promise in improving patients' lives, but a cure is still not available.

research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease

3 citations , March 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Zebrafish are useful for studying and developing treatments for human skin diseases.

research Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery

November 2025 in “Journal of Clinical Medicine”

Advancements in regenerative science and longevity research can improve healthspans, but must be balanced with ethics and safety.

research Abstracts

2 citations , January 2019 in “Medizinische Genetik”

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

research Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation

25 citations , February 2025 in “Frontiers in Bioengineering and Biotechnology”

New skin repair methods show promise but need to be safer and more accessible.

research Editorial overview: Embroidering the canvas of life

October 2018 in “Current Opinion in Genetics & Development”

The document emphasizes the importance of ongoing research and ethical considerations in genome editing and cellular reprogramming.

research Hutchinson-Gilford syndrome: History, causes, phenotype and research advances

June 2023 in “GSC Advanced Research and Reviews”

Hutchinson-Gilford Progeria Syndrome causes rapid aging from a genetic mutation, with no cure but ongoing research into potential treatments.

research Life Sciences Discovery and Technology Highlights

March 2019 in “SLAS TECHNOLOGY”

New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.

research Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

67 citations , June 2019 in “Proceedings of the National Academy of Sciences”

A new 3D culture system helps grow and study mouse skin stem cells for a long time.

research A Profuse Pipeline of Promising Options

January 2022 in “Sustainable development goals series”

The document concludes that significant investment in agricultural innovation is necessary to achieve global food security and nutrition.

research 312 CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

1 citations , September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.