Advances in Regenerative Medicine-Based Approaches for Skin Regeneration and Rejuvenation

    February 2025 in “ Frontiers in Bioengineering and Biotechnology ”
    Nathalia Silva Dutra Alves, Gustavo Roncoli Reigado, Mayara Santos, Izabela Daniel Sardinha Caldeira, Henrique dos Santos Hernandes, Bruna Letícia Freitas, E. Zhivov, Felipe S. Chambergo, Viviane Abreu Nunes
    TLDR New skin repair methods show promise but need to be safer and more accessible.
    The review highlights significant advancements in regenerative medicine for skin regeneration and rejuvenation, focusing on technologies like stem cell therapy, bioengineered skin substitutes, PRP, exosome-based therapies, and gene editing techniques such as CRISPR. These approaches show promise in treating chronic wounds, burns, age-related skin changes, and genetic disorders by promoting faster healing, reducing scarring, and improving skin integrity and aesthetics. Mesenchymal stem cells (MSCs) and adipose-derived stem cells (ADSCs) are emphasized for their potential in enhancing skin regeneration, reducing wrinkles, and treating conditions like alopecia areata, with studies showing significant improvements in hair growth and skin health. Despite these advancements, challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.
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