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A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.

New genes and pathways are important for testosterone production and male sexual development.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

A 10-year-old boy with abnormal genital development had surgery and tests to find the cause and plan treatment.

Men over 50 often experience urinary issues due to prostate enlargement or bladder problems, treatable with therapies, medications, or surgery.

Older men with high total testosterone might not show symptoms, while younger men with hyperandrogenism may experience hair loss or acne.

The review discusses how facial masculinization surgeries are done and their costs.

Some antiandrogens may lower testosterone better than others, but it's unclear which is best for feminization in transgender women; more research is needed.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

An ovarian tumor caused a woman's male-like symptoms, which improved after surgery.

A 71-year-old woman developed male-like features due to high testosterone levels caused by a benign ovarian tumor, which was successfully removed by surgery.

The document concludes that respectful, gender-affirming healthcare improves mental health and encourages continued medical care for transgender and non-binary individuals.

Postmenopausal virilization can be caused by ovarian hyperthecosis, treatable with surgery.

Finasteride may cause breast enlargement, low testosterone a risk factor.

Transgender individuals face unique skin issues, often due to hormone therapy, requiring specialized and stigma-free dermatologic care.

A 36-year-old person with a female appearance but male chromosomes was diagnosed with a rare enzyme deficiency affecting sexual development.

Gender-affirming hormone therapy and surgery affect gut bacteria differently.

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

A postmenopausal woman's virilization was caused by a rare ovarian tumor that was hard to detect but was successfully treated with surgery.

Hormonal treatments can change hair and skin in transgender people, but may not fully achieve desired results.

Thorough evaluation is crucial for postmenopausal women with virilization to detect rare ovarian tumors.

A woman developed male traits from accidental contact with her husband's testosterone gel.

Transgender men on testosterone therapy need ongoing gynecologic care due to potential cancer risks.

Doctors are preparing to potentially perform uterus transplants in transgender women, considering technical, hormonal, and ethical factors.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.