July 2025 in “International Journal of Trichology” Biological factors are crucial for developing new hair restoration treatments.
2 citations
,
November 2022 in “Journal of Biochemistry and Molecular Biology” Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.
426 citations
,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
74 citations
,
October 2023 in “Nature Reviews Molecular Cell Biology” 19 citations
,
August 2024 in “Journal of Translational Medicine” Epidermal stem cells are vital for skin healing and have potential for treating skin disorders.
7 citations
,
May 2022 in “Frontiers in Cell and Developmental Biology” Epigenetic and metabolic changes affect stem cell function and aging in skin.
5 citations
,
April 2024 in “Biology” Improving human hair follicle models is crucial for better hair loss treatments.
4 citations
,
July 2022 in “Annals of translational medicine” Scientists created complete hair-like structures by growing mouse skin cells together in a special gel.
June 2025 in “Biomolecules” RORA affects hair follicle stem cells' structure and movement, potentially helping treat hair loss.
April 2025 in “Indian Dermatology Online Journal” Bird-related analogies help explain and remember skin conditions better.
February 2025 in “Biomolecules” Melatonin can help or hinder hair growth depending on the dose.
December 2024 in “Animals” RORA may help regulate hair growth by affecting hair follicle stem cells.
July 2022 in “Biomedicines” 4-Aminopyridine improves skin wound healing and tissue regeneration by increasing cell growth and promoting nerve repair.
June 2025 in “Stem Cell Research & Therapy” Isoproterenol may help treat hair loss by activating hair follicle stem cells.
January 2022 in “Stem cell biology and regenerative medicine” Lymphatic vessels help hair follicles regenerate by interacting with stem cells.
92 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
31 citations
,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
31 citations
,
July 2017 in “Stem cell investigation” Platelet-rich plasma (PRP) is a simple, cost-effective treatment that promotes hair growth and reduces hair loss, with high patient satisfaction.
25 citations
,
June 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
23 citations
,
October 2021 in “Cell Stem Cell” Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
9 citations
,
February 2021 in “Frontiers in Cell and Developmental Biology” Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.
7 citations
,
July 2025 in “The Journal of Physiology” C-tactile nerves are sensitive to hair movement.
4 citations
,
December 2022 in “International Journal of Molecular Sciences” Zinc is crucial for skin health and treating various skin disorders.
4 citations
,
July 2022 in “Frontiers in Cell and Developmental Biology” The document concludes that understanding adult stem cells and their environments can help improve skin regeneration in the future.
2 citations
,
June 2021 in “Cosmoderma” Platelet-rich plasma (PRP) shows promise in skin and hair treatments but results vary with preparation methods.
1 citations
,
October 2022 in “Annual review of cell and developmental biology” The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
Stress can cause hair loss and trigger autoimmunity by damaging hair follicle cells.
November 2025 in “Biomolecules” FGF22 helps hair follicle stem cells grow and develop.
October 2025 in “Nature Reviews Disease Primers” August 2025 in “Biomolecules” Fibroblast growth factors could be a better, safer treatment for hair loss than current options.