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GlossaryHaCaT keratinocytes

immortalized human skin cells used in research

HaCaT keratinocytes are a type of human skin cell that has been immortalized, meaning they can divide indefinitely in laboratory conditions. These cells are commonly used in scientific research to study skin biology, wound healing, and diseases like psoriasis and skin cancer because they closely mimic the behavior of normal human skin cells.

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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E₂through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations , November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research Metabolic pathway of Cis-UCA upon Ultraviolet B (UVB) exposure using ¹H Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Docking and cell viability of human keratinocytes (HaCaT) cell lines

February 2026 in “UiTM Institutional Repositories (Universiti Teknologi MARA)”

Cis-UCA can form new compounds without enzymes, and sulphide donors reduce its UVB-induced toxicity in skin cells.

Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT

research 1316 Aqueous extract of Mentha suaveolens induces Nrf-2 activation and expression of antioxidant and detoxifying enzymes in human keratinocyte HaCaT

April 2018 in “Journal of Investigative Dermatology”

Mint water extract boosts protective enzymes in skin cells.

research Regulatory effect of 4-O-methylhonokiol on TGF-β1-induced cell cycle arrest in human keratinocyte cell line (HaCaT)

August 2011 in “Planta Medica”

4-O-methylhonokiol from Magnolia Officinalis may promote hair growth by interfering with TGF-β1 effects in skin cells.

research Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments

January 2020 in “Open University of Cape Town (University of Cape Town)”

Efficient culture methods are needed to keep human keratinocytes undifferentiated for hair follicle induction.

research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

6 citations , November 2022 in “Antioxidants”

OR2AT4 helps reduce aging and cell damage in human skin cells.

research Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

40 citations , July 2015 in “Journal of Cellular Biochemistry”

Cysteine helps maintain keratin production in skin cells even when iron is low.

research HaCaT keratinocytes express functional receptors for thyroid-stimulating hormone

6 citations , May 2010 in “Journal of Dermatological Science”

Human skin cells can respond to thyroid-stimulating hormone, affecting hair and skin health.

research 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation

September 2017 in “Journal of Investigative Dermatology”

Mackerel fermented fish oil protects skin cells from damage by UVB light.

research Transport of Biotin in Human Keratinocytes

53 citations , March 2003 in “Journal of Investigative Dermatology”

Human skin cells have a high-affinity system for biotin transport, crucial for skin health.

research Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model

3 citations , September 2024 in “Journal of Microbiology and Biotechnology”

Human placenta extract reduces inflammation and symptoms in atopic dermatitis.

research Protective Effect of Polysaccharide Derived from Natural Extract on Human Follicle Dermal Papilla Cell and Keratinocytes

December 2022 in “Korean journal of medicinal crop science/Han-gug yagyong jagmul hag-hoeji”

Natural extracts like ginseng, green tea, shiitake, and aloe vera may help prevent hair loss by protecting hair-related cells.

Gene Expression Profiling of Human Keratinocytes Exposed to the Hair-Dyeing Agent, m-Aminophenol

research Gene expression profiling of human keratinocytes exposed to the hair-dying agent, m-aminophenol

March 2013 in “Molecular & Cellular Toxicology/Molecular & cellular toxicology”

m-Aminophenol in hair dye can cause skin cell toxicity and stress responses.

research Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53

2 citations , August 2019 in “BMC Complementary and Alternative Medicine”

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.

Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

research Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

7 citations , January 2018 in “Medicinski arhiv”

A herbal extract may help treat certain types of hair loss by reducing a specific gene's activity.

Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

research Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

April 2026 in “Dove Medical Press (Taylor and Francis Group)”

Myrtus communis leaf extract may help with hair loss and wound healing.

research Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells

16 citations , April 2017 in “Journal of Cosmetic Dermatology”

Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.

research Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor

19 citations , January 2012 in “Dermatology”

Topical human epidermal growth factor may effectively treat acne caused by cancer medication.

Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Implications for Hair Loss and Wound Healing

research Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

April 2026 in “Clinical Cosmetic and Investigational Dermatology”

Myrtus communis leaf extract may help with hair loss and wound healing.

research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations , May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebocytes play a key role in controlling androgen levels in human skin.

research A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control

2 citations , September 2004 in “Experimental Dermatology”

VR1 signaling can inhibit hair growth by affecting cell processes and increasing hair growth inhibitors.

research Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

31 citations , January 2014 in “The Scientific World JOURNAL”

Eclipta prostrata extract protects skin cells from UVB damage and has strong antioxidant properties.

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

10 citations , February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis

13 citations , August 1999 in “Journal of Investigative Dermatology”

Bikunin is found on the cell boundaries of certain skin layers and may help regulate skin and hair functions.

research Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers

4 citations , October 2017 in “Advances in tissue engineering & regenerative medicine”

Researchers created a potential skin substitute using a biodegradable mat that supports skin cell growth and layer formation.

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research Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E₂through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Metabolic pathway of Cis-UCA upon Ultraviolet B (UVB) exposure using ¹H Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Docking and cell viability of human keratinocytes (HaCaT) cell lines

research 1316 Aqueous extract of Mentha suaveolens induces Nrf-2 activation and expression of antioxidant and detoxifying enzymes in human keratinocyte HaCaT

research Regulatory effect of 4-O-methylhonokiol on TGF-β1-induced cell cycle arrest in human keratinocyte cell line (HaCaT)

research Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments

research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

research Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

research HaCaT keratinocytes express functional receptors for thyroid-stimulating hormone

research 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation

research Transport of Biotin in Human Keratinocytes

research Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model

research Protective Effect of Polysaccharide Derived from Natural Extract on Human Follicle Dermal Papilla Cell and Keratinocytes

research Gene expression profiling of human keratinocytes exposed to the hair-dying agent, m-aminophenol

research Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53

research Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

research Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

research Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells

research Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor

research Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin

research A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control

research Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

research Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis

research Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers

research Microalgae, Tetraselmis tetrathele has Alopecia Prevention and Scalp Improvement

research The hair growth promoting effect of extract and its molecular regulation

research The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity

research Lack of androgen receptor transcriptional activity in human keratinocytes

research Downregulation of nuclear factor-kappaB activation in human keratinocytes by melanogenesis inhibitors