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GlossaryAnagen Hair Follicles

phase where hair actively grows

Anagen hair follicles, also known as growing hair follicles or active hair follicles, are in the phase of the hair growth cycle where the hair is actively growing. This phase can last anywhere from 2 to 7 years, during which the hair shaft is continuously produced by the follicle, resulting in longer hair. This is the most prolonged phase of the hair cycle and is crucial for determining the length of the hair.

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CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

research CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

3 citations , April 2014 in “Journal of Dietary Supplements”

CARI ONE helps start hair growth and makes hair follicles bigger and more numerous.

research Interleukin 6 induces the hair follicle growth phase (anagen)

12 citations , June 2006 in “Journal of Dermatological Science”

Interleukin 6 helps hair grow.

research PDGF isoforms induce and maintain anagen phase of murine hair follicles

136 citations , June 2006 in “Journal of Dermatological Science”

PDGF isoforms can promote and sustain hair growth.

Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

research Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2025 in “MEDS Public Health and Preventive Medicine”

Spermidine supplements can help extend the hair growth phase and may be useful for treating hair loss.

research Histochemistry of the human hair follicle with consideration of anagen phases I to VI

18 citations , June 1992 in “Acta Histochemica”

Human hair follicles have a unique cell distribution and differentiation pattern during growth.

research The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears

10 citations , November 2008 in “Veterinary Dermatology”

The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.

A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

research A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

8 citations , October 2017 in “Dermatology practical & conceptual”

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

research 575 An extract of Leontopodium alpinum prolongs anagen phase in human hair follicles ex vivo

April 2021 in “Journal of Investigative Dermatology”

Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.

research Effect of Plantago asiatica L. extract on the anagen phase in human hair follicle dermal papilla cells

5 citations , March 2023 in “Journal of Cosmetic Dermatology”

Plantago asiatica L. extract can promote hair growth by enhancing the anagen phase.

Pea Sprout Extract Promotes Hair Follicle Regeneration Via Anagen Phase Prolongation And Dual Modulation Of Oxidative And Inflammatory Signaling

research Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling

November 2025 in “Journal of Microbiology and Biotechnology”

Pea sprout extract may help hair regrow by reducing stress and inflammation.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

Gamma-ray exposure during hair rest phase harms hair growth and color in mice.

research Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

June 2017 in “Experimental and Therapeutic Medicine”

The anti-CXCL4 antibody helps mice grow hair faster and prevents hair loss.

research Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen

9 citations , August 2005 in “Experimental Dermatology”

Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Plet-1 protein helps hair follicle cells move and stick to tissues.

research Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling

20 citations , November 2019 in “Stem Cells”

Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.

STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

research 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing

1 citations , August 2016 in “Journal of Investigative Dermatology”

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

STAT5 activation is crucial for starting the hair growth phase.

research Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)

14 citations , January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.

research An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal

January 1996

The estrogen receptor pathway controls hair growth cycles and affects skin cell growth.

research Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles

28 citations , November 2012 in “Experimental dermatology”

A protein complex called mTORC1 likely affects when hair growth starts in mice.

research Immunization by Application of DNA Vaccine onto a Skin Area Wherein the Hair Follicles Have Been Induced into Anagen-onset Stage

20 citations , August 2007 in “Molecular therapy”

Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.

research IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles

9 citations , August 2023 in “Journal of Investigative Dermatology”

IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.

research TGF‐β and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage

10 citations , February 2019 in “Journal of cellular physiology”

TGF-β2 helps yak hair follicles enter the regression phase, while HSP70 tries to prevent it.

In Vitro Methodology, Hormonal and Nutritional Effects, and Fiber Production in Isolated Ovine and Caprine Anagen Hair Follicles

research In vitro methodology, hormonal and nutritional effects and fibre production in isolated ovine and caprine anagen hair follicles

7 citations , January 2010 in “Animal”

Angora goat hair grows faster and produces more protein than cashmere goat hair, and certain hormones and nutrients positively affect hair growth and protein synthesis.

Estetrol Prolongs Anagen in Healthy Female Scalp Hair Follicles by Positively Modulating Dermal Papilla Functions and Generation of Progenitor Stem Cells Ex Vivo

research 1386 Estetrol prolongs anagen in healthy female scalp hair follicles by positively modulating dermal papilla functions and generation of progenitor stem cells ex vivo

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Estetrol may help prevent hair loss and promote hair growth in women.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

BMP signaling prevents hair growth by stopping stem cell activation.