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Did you mean Hair Matrix Keratinocytes?

GlossaryHair Matrix Keratinocytes

specialized cells producing keratin for hair growth

Hair Matrix Keratinocytes are specialized cells located at the base of the hair follicle. These cells are responsible for producing the keratin proteins that make up the hair shaft, essentially driving hair growth. They rapidly divide and differentiate, contributing to the formation and elongation of the hair strand.

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Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells

31 citations , December 1991 in “Annals of the New York Academy of Sciences”

ORS and hair matrix cells balance growth and differentiation better than normal keratinocytes, with human dermal fibroblasts crucial for proper differentiation.

research 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican

July 2024 in “Journal of Investigative Dermatology”

Versican in dermal papilla cells is crucial for healthy hair growth.

research Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity

4 citations , July 2025 in “Frontiers in Pharmacology”

Cooling with antioxidants helps protect hair during chemotherapy.

research Melatonin protects K15+ human hair follicle stem cells and hair matrix keratinocytes against paclitaxel-induced damage ex vivo

1 citations , September 2023 in “Journal of Investigative Dermatology”

Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle

52 citations , October 2005 in “Journal of Investigative Dermatology”

Hair follicle stem cells have greater longevity and adhesion, while transit-amplifying cells are more mobile.

Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

research Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice

24 citations , December 2014 in “International Journal of Molecular Medicine”

Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

research Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles

8 citations , March 2019 in “Journal of Biomedical Materials Research Part A”

Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.

research [Three-dimensional culture of plucked human hair follicles inside the collagen gel matrix].

3 citations , July 1990 in “PubMed”

Human hair follicles can grow and form structures in a collagen gel, useful for studying hair cell growth.

research Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis

41 citations , July 1994 in “Journal of Dermatological Science”

Hair follicle cells need complex interactions to fully differentiate.

research Keratinocytes-hair follicle bulge stem cells-fibroblasts co-cultures on a tri-layer skin equivalent derived from gelatin/PEG methacrylate nanofibers

11 citations , February 2020 in “Journal of Biomaterials Science Polymer Edition”

The new GelMet hydrogel can effectively support skin cell growth for tissue engineering.

research Ginsenosides Rb₁ and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

15 citations , September 2012 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research A simple assay for the study of human hair follicle damage induced by ionizing irradiation

16 citations , November 2009 in “Experimental dermatology”

Ionizing radiation damages human hair follicles by stopping cell growth, causing cell death, disrupting color, and increasing stress and damage markers.

Induction of Hair Growth in Hair Follicle Cells and Organ Cultures Upon Treatment with 30 kHz Frequency Inaudible Sound via Cell Proliferation and Antiapoptotic Effects

research Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects

January 2022 in “Biomedical Reports”

Inaudible sound at 30 kHz can boost hair growth and decrease hair loss by promoting cell growth and reducing cell death in hair follicles.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles

research Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

49 citations , November 2014 in “Journal of Medicinal Food”

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

research Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

42 citations , March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

research Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

17 citations , February 2018 in “Journal of Investigative Dermatology”

PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

research NF-κB Activity Is Required for Anagen Maintenance in Human Hair Follicles In Vitro

15 citations , February 2014 in “Journal of Investigative Dermatology”

NF-κB activity is crucial for keeping hair in the growth phase.

The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research 805 Topical thyroid hormones promote hair follicle and epithelial hair follicle stem cell growth in intact human scalp skin ex vivo

July 2024 in “Journal of Investigative Dermatology”

Topical thyroid hormones may boost hair growth.

research 185 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo

November 2023 in “Journal of Investigative Dermatology”

γδTregs can protect hair follicles from alopecia areata and may help regrow hair.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

Human Hair Follicles Can Taste: Stimulation of the Bitter Taste Receptor TAS2R4 Inhibits Hair Growth Ex Vivo by Up-Regulating TGF-β2

research 571 Human Hair Follicles can “Taste”: Stimulation of the Bitter Taste Receptor TAS2R4 Inhibits Hair Growth Ex Vivo by Up-Regulating TGF-β2

November 2022 in “Journal of Investigative Dermatology”

Activating a bitter taste receptor in hair follicles can stop hair growth by increasing a specific growth factor.

research 575 An extract of Leontopodium alpinum prolongs anagen phase in human hair follicles ex vivo

April 2021 in “Journal of Investigative Dermatology”

Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.