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GlossaryHair Follicle Stem Cell Differentiation

process where stem cells become specialized hair cells

Hair follicle stem cell differentiation is the process by which stem cells in the hair follicle develop into specialized cells that form the various structures of the hair, such as the hair shaft and the surrounding skin. This process is crucial for hair growth and regeneration, as it allows the hair follicle to produce new hair after shedding or damage.

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Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

95 citations , January 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

Androgens prevent hair growth by changing Wnt signals in cells.

research Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation

1 citations , April 2022 in “Cell Death Discovery”

Increasing Smurf2 hinders hair follicle stem cell differentiation and wound healing.

research Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

42 citations , July 2010 in “European Journal of Cell Biology”

Thyroid hormones affect hair follicle stem cells by promoting differentiation and reducing growth.

research In vitro neural differentiation of CD34 + stem cell populations in hair follicles by three different neural induction protocols

18 citations , October 2014 in “In vitro cellular & developmental biology. Animal”

Hair follicle stem cells can become neural cells using different methods, with varying efficiency.

research miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5

19 citations , May 2018 in “Molecular Medicine Reports”

miR‑339‑5p can slow down hair follicle stem cell differentiation by targeting DLX5.

research In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin

10 citations , October 2019 in “Iranian Biomedical Journal”

Simvastatin helps hair follicle stem cells turn into skin cells.

research MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation

2 citations , February 2022 in “Human Gene Therapy”

Increasing miR-149 reduces hair follicle stem cell growth and hair development by affecting certain cell growth pathways.

research miR-133a-3p and miR-145-5p co-promote goat hair follicle stem cell differentiation by regulating NANOG and SOX9 expression

November 2023 in “Animal Bioscience”

miR-133a-3p and miR-145-5p help goat hair follicle stem cells differentiate by controlling NANOG and SOX9.

research Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB

19 citations , September 2013 in “Molecular Medicine Reports”

Human hair follicle stem cells can become smooth muscle cells using specific growth factors.

research FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

November 2025 in “Biomolecules”

FGF22 helps hair follicle stem cells grow and develop.

Glypican-1, -4, and -6 Participate in Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7, and Patched 1

research Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1

October 2024 in “SPIRE - Sciences Po Institutional REpository”

Glypicans help hair follicle stem cells differentiate by interacting with specific receptors, influencing hair growth.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777]

1 citations , November 2012 in “European Journal of Cell Biology”

The authors clarified data overlap and corrected a figure error, apologizing for any confusion.

Ionizing Radiation Triggers Dedifferentiation of Outer Root Sheath Cells Into Stem Cell-Like Progenitors for Hair Follicle Regeneration

research 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration

April 2017 in “Journal of Investigative Dermatology”

research Exploring the Differentiation Abilities of Hair Follicle and Dental Pulp Stem Cells Into Islet Like Cells

1 citations , February 2025 in “Cell Biology International”

Hair follicle stem cells are better than dental pulp stem cells at becoming insulin-producing cells, useful for diabetes therapy.

research Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation

13 citations , December 2017 in “Stem cells”

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

research Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS

9 citations , March 2019 in “Scientific reports”

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

research DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

8 citations , October 2020 in “Stem cell research & therapy”

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

research Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles

34 citations , June 2008 in “In vitro cellular & developmental biology. Animal”

Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.

research Highly Efficient Neural Differentiation of CD34-Positive Hair-Follicle-Associated Pluripotent Stem Cells Induced by Retinoic Acid and Serum-Free Medium

4 citations , January 2016 in “Methods in molecular biology”

Hair follicle stem cells can become nerve cells using specific treatments.

research Spatiotemporal immunomodulation by engineered hair follicle stem cell-derived nanovesicles enables scarless regeneration of infected wounds

January 2026 in “Chemical Engineering Journal”

Engineered nanovesicles from hair follicle stem cells enable scarless healing of infected wounds.

research N1-acetylspermidine is a determinant of hair follicle stem cell fate

17 citations , May 2021 in “Journal of Cell Science”

N1-acetylspermidine promotes hair follicle stem cell self-renewal.

research Coordinating Stem Cell Behavior in the Hair Follicle

September 2025 in “Digital Commons - RU (Rockefeller University)”

Nfib in hair follicle stem cells boosts melanocyte stem cell growth and differentiation.

research Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging

3 citations , July 2023 in “Frontiers in Aging”

Hair follicle stem cells change states with age, affecting hair growth and aging.

research An induced pluripotent stem cell-based approach for hair follicle development and regeneration

June 2024 in “Regenerative Therapy”

iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.

research Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma

45 citations , October 2019 in “Clinical and Experimental Dermatology”

Targeted therapies promoting differentiation could help treat basal cell carcinoma by exhausting cancer stem cells.

research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.

Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells

research Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells

9 citations , September 2021 in “Stem Cell Reviews and Reports”

Hair follicle stem cells from aged eyelid skin can become corneal endothelial-like cells for potential eye treatments.

research Neural Potential of a Stem Cell Population in the Hair Follicle

80 citations , September 2007 in “Cell Cycle”

Stem cells in hair follicles can become various cell types, including neurons.