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GlossaryHippo signaling pathway

biological system controlling cell growth, division, and death

The Hippo signaling pathway is a biological system that controls cell growth, division, and death, playing a crucial role in regulating organ size and tissue regeneration. It involves a series of proteins that communicate signals from the cell surface to the nucleus, ensuring that cells stop growing when they reach a certain size, which helps prevent cancer and other diseases.

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research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

7 citations , August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

2 citations , January 2025 in “动物学研究”

YAP1 helps fat cell formation by influencing the Hippo pathway.

research YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

14 citations , November 2024 in “International Journal of Molecular Sciences”

YAP and TAZ proteins control skin cell growth and repair.

research Roles of Hippo signaling pathway in size control of organ regeneration

37 citations , April 2015 in “Development Growth & Differentiation”

The Hippo signaling pathway helps control organ size during regeneration by regulating gene expression.

research Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

research TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs

September 2025 in “Stem Cell Research & Therapy”

TAZ boosts fat cell formation in goat stem cells by activating a specific signaling pathway.

research Tail Tales: What We Have Learned About Regeneration from Xenopus Laevis Tadpoles

3 citations , October 2024 in “International Journal of Molecular Sciences”

Xenopus laevis tadpoles can regenerate complex tail structures, offering insights for regenerative medicine.

research Computational derivation of a molecular framework for hair follicle biology from disease genes

4 citations , November 2017 in “Scientific Reports”

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

research YAP and TAZ are essential for basal and squamous cell carcinoma initiation

76 citations , June 2018 in “EMBO Reports”

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

research Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells

8 citations , May 2013 in “Journal of Investigative Dermatology”

Different problems with hair stem cell renewal can lead to hair loss.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances

February 2026 in “Exploration”

Advancements in gene therapy, stem cells, and biomaterials show promise for reducing scarring in wound healing, but face clinical challenges.

research Integrin signalling regulates YAP/TAZ to control skin homeostasis

266 citations , January 2016 in “Development”

YAP and TAZ are crucial for skin cell growth and repair.

Cold Atmospheric Microwave Plasma Stimulates Dermal Papilla Cell Proliferation by Inducing Beta-Catenin Signaling

research Cold atmospheric microwave plasma (CAMP) stimulates dermal papilla cell proliferation by inducing β-catenin signaling

February 2023 in “Scientific Reports”

Cold Atmospheric Microwave Plasma (CAMP) helps hair cells grow and could potentially treat hair loss.

A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth

research A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth

30 citations , May 2018 in “Experimental Dermatology”

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

research Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type

41 citations , October 2019 in “Biomolecules”

Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.

research Epithelial Fibronectin meshwork controls skin regeneration

April 2025 in “Journal of Investigative Dermatology”

Fibronectin is essential for hair follicle regeneration by supporting stem cells.

research Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

37 citations , February 2024 in “Military Medical Research”

Biomaterials can help heal wounds without scars and regenerate skin features.

research Ontogeny of Skin Stem Cells and Molecular Underpinnings

7 citations , July 2024 in “Current Issues in Molecular Biology”

Understanding skin stem cells and their regulation is key to improving skin healing and treating disorders.

Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion by Inhibiting Autophagy in Endometrial Stromal Cells

research Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

52 citations , September 2020 in “Cell Death and Disease”

Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.

research Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis

October 2025 in “Clinical Cosmetic and Investigational Dermatology”

Targeting specific cell interactions may help treat skin fibrosis.

Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

research Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia

February 2025 in “FASEB BioAdvances”

Verteporfin reduces growth and stem cell traits in rat hair follicle cells by blocking the Hippo pathway.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations , November 2017 in “Journal of developmental biology”

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Molecular Pathology of Skin Adnexal Tumors

research Molecular pathology of skin adnexal tumours

16 citations , July 2021 in “Histopathology”

New markers and pathways have been found in skin tumors, helping better understand and diagnose them.

XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity

research XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

4 citations , September 2020 in “Cell division”

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.