research Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis
Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.
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research The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature
Heat Shock Proteins are important in the development of Polycystic Ovarian Syndrome and could be targets for new treatments.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
research Characterization of novel TMEM173 mutation with additive IFIH1 risk allele
A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.
research Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled
Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.
research A genetic electrophoretic variant of high-sulfur hair proteins for forensic hair comparisons. I. Characterization of variant high-sulfur proteins of human hair.
A genetic hair protein variant is more common in Japanese people and is inherited.
research Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia
A single amino acid change in the vitamin D receptor can disrupt its function and lead to hair loss.
research Study on Changes of 19 Steroids in Plasma From 9 Diagnosed Patients With P450 Oxidoreductase Deficiency
Certain hormone levels can help diagnose P450 oxidoreductase deficiency.
research The Evaluation and Treatment of Hirsute Women
Excessive body hair in women can be caused by various conditions and treated with medication like Diane® 35 or androgen blockers.
research Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer
research Sexual dimorphism following in vitro ischemia in the response to neurosteroids and mechanisms of injury
Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.
research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway
New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.
research Orai1 expression pattern in tooth and craniofacial ectodermal tissues and potential functions during ameloblast differentiation
Orai1 protein is crucial for tooth development and affects enamel thickness and mineralization.
research Hirsuties
Hirsutism in women is often due to hormone sensitivity and has significant psychological effects.
research Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont
Hydra can help understand human hair follicle microbiomes and develop new skin disease therapies.
research Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation between Vitamin D Receptor and Hairless Protein
Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.
research Insulin resistance and hair disorders, idiopathic hirsutism, and androgenic alopecia
There is no significant link between insulin resistance and certain hair disorders like idiopathic hirsutism and androgenic alopecia.
research Against the Rules: Human Keratin K80
Keratin K80 is an ancient protein found in various tissues, important for cell structure and tissue differentiation.
research Molecular expression associated with vibrissa follicle development and differentiation
Id proteins, especially Id2 and Id3, are crucial for hair follicle development and stem cell regulation.
research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.
Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
research Treatment of hirsutism and acne in women with two combinations of cyproterone acetate and ethinylestradiol.
Cyproterone acetate and ethinylestradiol effectively reduce hirsutism and acne in women.
research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
High levels of ODC and a mutant Ha-ras gene cause tumors in mice.
research The Fate of Trichohyalin
Trichohyalin is modified by enzymes to form strong structures in hair cells.
research 675 Hair loss in hephaestin knockout mice is associated with iron deficiency
Iron deficiency causes hair loss by affecting hair differentiation and cycling.
research Close correlation between hyperandrogenism and insulin resistance in women with polycystic ovary syndrome—Based on liquid chromatography with tandem mass spectrometry measurements
Women with PCOS who have high male hormone levels often also have insulin resistance.
research Diagnosis and treatments of hirsutism: where are we?
Effective treatments for excessive hair growth in women include creams, laser therapy, and medications, with the choice depending on individual needs and potential side effects.
research Neurosteroids as Endogenous Regulators of Seizure Susceptibility
Stress increases neurosteroids that help prevent seizures.
research [Hirsutism].
Hirsutism, often caused by PCOS, is treated with medication and weight loss is important for obese women with PCOS.
research Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.