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,
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,
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,
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,
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,
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202 citations
,
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184 citations
,
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,
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144 citations
,
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,
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124 citations
,
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,
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112 citations
,
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106 citations
,
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104 citations
,
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86 citations
,
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84 citations
,
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81 citations
,
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76 citations
,
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72 citations
,
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70 citations
,
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69 citations
,
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65 citations
,
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59 citations
,
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55 citations
,
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55 citations
,
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48 citations
,
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48 citations
,
September 2017 in “Frontiers in Bioscience” Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.
46 citations
,
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44 citations
,
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