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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Efficacy and Acceptability of a New Water-Soluble Nail Strengthener Containing Pistacia lentiscus and Hyaluronic Acid to Improve the Appearance of Brittle Nails versus Untreated Nails: In vitro and Clinical Evidence

5 citations , January 2020 in “Skin Appendage Disorders”

The nail strengthener with Pistacia lentiscus and hyaluronic acid improves brittle nails' appearance and strength.

Antibacterial Effects of Ethanolic Extracts of Ziziphus Jujuba, Medicago Sativa, Reum Ribes, and Hyssopus Officinalis on Some Standard Gram-Positive and Gram-Negative Bacteria In Vitro

research Antibacterial Effects of Ethanolic Extracts of Ziziphus jujuba, Medicago sativa, Reum ribes and Hyssopus officinalis on Some Standard Gram-Positive and Gram-Negative Bacteria in Vitro

4 citations , July 2021 in “Armaghane Danesh”

These plant extracts can kill some bacteria.

research Cell/Tissue Microenvironment Engineering and Monitoring in Tissue Engineering, Regenerative Medicine, and In Vitro Tissue Models

4 citations , January 2014 in “BioMed Research International”

Engineering the cell microenvironment is key for advancing tissue engineering and regenerative medicine.

research [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies].

4 citations , January 2006 in “PubMed”

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

3 citations , April 2016 in “Research and reports in urology”

The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.

Brassica Oleracea Extract, Glucosinolates, And Sulforaphane Promote Hair Growth In Vitro And Ex Vivo

research Brassica oleracea extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo

2 citations , April 2021 in “Journal of Cosmetic Dermatology”

Brassica oleracea extract, glucosinlates, and sulforaphane can boost hair growth and might be used to treat hair loss.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

2 citations , April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

research Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777]

1 citations , November 2012 in “European Journal of Cell Biology”

The authors clarified data overlap and corrected a figure error, apologizing for any confusion.

research Phytochemical profiling, green synthesis of Ag, Cu, Fe, and Zn nanoparticles, and in vitro biological activities of Delphinium brunonianum Royle

May 2026 in “Scientific Reports”

Delphinium brunonianum shows promise for medical use due to its bioactive compounds and effective nanoparticle synthesis.

research Experimental and Finite Element Analysis of a Residual Hair Keratin‐based Hydrogel with Calcium for Atorvastatin Sequestration, Release, and In Vitro Activity

February 2026 in “Macromolecular Bioscience”

Keratin-based hydrogels with calcium are effective for delivering anti-fibrotic drugs.

Harnessing miRNAs' Milk-Derived Exosomes for Hair Loss Disorders: In Vitro Modulation of WNT Signaling and Dermal Papilla Proliferation

research Harnessing miRNAs’ S Milk-Derived Exosomes for Hair Loss Disorders: In Vitro Modulation of WNT Signaling and Dermal Papilla Proliferation

December 2025 in “Preprints.org”

Milk-derived exosomes may help treat hair loss by boosting hair cell growth and signaling.

research Shrimp-derived extracts as antibacterial, antioxidant, and burn wound-healing agents: Comprehensive in vitro and in vivo evaluation from Yemeni coastal resources.

December 2025 in “Pharmacological Research - Natural Products”

Shrimp extracts may help heal burns and fight bacteria.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro</i>, and In Silico* Studies*

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells in vitro
June 2025 in “Medical academic journal”

Modified liposomes with exosomes effectively deliver RNA to stem cells.

research Pengaruh Ekstrak Metanol Batang Etlingera alba (Blume) A. D. Poulsen Terhadap Penekanan Genicaspase-3 sebagai Penanda Apoptosis pada Lini Sel Kanker Payudara T47D Secara In Vitro
June 2025 in “Jurnal Mandala Pharmacon Indonesia”

Etlingera alba extract may help treat breast cancer with fewer side effects.

research Evaluation of Efficacy of Water-Soluble Fraction of Rhus semialata Gall Extract and Penta-O-Galloyl-β-D-Glucose on Mitigation of Hair Loss: An In Vitro and Randomized Double-Blind Placebo-Controlled Clinical Study
April 2025 in “Antioxidants”

Rhus semialata gall extract and Penta-O-Galloyl-β-D-Glucose may effectively reduce hair loss.

research A Novel Topical Compound Gel Loading Minoxidil and Tofacitinib for Treatment of Alopecia Areata: Formulation, Characterization, and In Vitro/In Vivo Evaluation
March 2025 in “Drug Development Research”

The new gel combining minoxidil and tofacitinib effectively treats alopecia areata by promoting hair growth and reducing inflammation.

research Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study
December 2024 in “International Journal of Molecular Sciences”

Platelet-rich fibrin may help reduce nonmelanoma skin cancer cell growth.

research Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study
October 2024 in “Aesthetic Plastic Surgery”

Micrografts are a safe and effective treatment for hair loss in both men and women.

research Study on the regulatory effect of Ligusticum chuanxiong on inflammation of human dermal papilla cells in alopecia areata based on network pharmacology and in vitro experiment
July 2024 in “Research Square”

research TỔNG QUAN VỀ SINH HỌC CỦA TÓC, MÔ HÌNH NGHIÊN CỨU VÀ ĐÁNH GIÁ KHẢ NĂNG MỌC LẠI TÓC TRÊN IN-VITRO VÀ IN-VIVO
May 2024 in “Tạp chí Y Dược học Cần Thơ”

Natural remedies like grapefruit and rosemary may help hair regrowth.

research The Potential Teeth Bleaching and Halitosis Prevention Effects of Pediococcus inopinatus THK-30, a Kimchi-Derived Lactic Acid Bacterium: In Vitro Study
March 2024 in “Journal of functional biomaterials”

A kimchi-derived bacterium could help whiten teeth and prevent bad breath.

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVECs angiogenesis in vitro
January 2021

Placental cell medium boosts blood vessel growth in lab tests.

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or placental tissue promoted HUVECs angiogenesis in vitro
August 2020

Placental components enhance blood vessel growth.

research 681 Inhibition of STAT3, using Oenocarpus bataua vegetable oil, on in vitro model
April 2016 in “Journal of Investigative Dermatology”

Oenocarpus bataua vegetable oil may help reduce hair loss by affecting a key gene pathway.

research Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies
March 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Lipid nanoparticles show promise for delivering alopecia treatments to the skin.

research Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"
February 2013

Activating CB1 can reduce keratin levels, potentially helping manage psoriasis and aid wound healing.

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"
February 2013

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

research Follicular penetration of nano-sized particulate FA-PLGA and the dye RhBITC in dorsal dog and rat skin, and porcine ear skin as an in vitro model for the human integument
January 2011

Hair follicles can effectively absorb nano-sized particles, making them potential targets for localized drug delivery.

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Research

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

research Efficacy and Acceptability of a New Water-Soluble Nail Strengthener Containing Pistacia lentiscus and Hyaluronic Acid to Improve the Appearance of Brittle Nails versus Untreated Nails: In vitro and Clinical Evidence

research Antibacterial Effects of Ethanolic Extracts of Ziziphus jujuba, Medicago sativa, Reum ribes and Hyssopus officinalis on Some Standard Gram-Positive and Gram-Negative Bacteria in Vitro

research Cell/Tissue Microenvironment Engineering and Monitoring in Tissue Engineering, Regenerative Medicine, and In Vitro Tissue Models

research [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies].

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

research Brassica oleracea extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

research Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777]

research Phytochemical profiling, green synthesis of Ag, Cu, Fe, and Zn nanoparticles, and in vitro biological activities of Delphinium brunonianum Royle

research Experimental and Finite Element Analysis of a Residual Hair Keratin‐based Hydrogel with Calcium for Atorvastatin Sequestration, Release, and In Vitro Activity

research Harnessing miRNAs’ S Milk-Derived Exosomes for Hair Loss Disorders: In Vitro Modulation of WNT Signaling and Dermal Papilla Proliferation

research Shrimp-derived extracts as antibacterial, antioxidant, and burn wound-healing agents: Comprehensive in vitro and in vivo evaluation from Yemeni coastal resources.

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro</i>, and In Silico* Studies*

research Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells in vitro

research Pengaruh Ekstrak Metanol Batang Etlingera alba (Blume) A. D. Poulsen Terhadap Penekanan Genicaspase-3 sebagai Penanda Apoptosis pada Lini Sel Kanker Payudara T47D Secara In Vitro

research Evaluation of Efficacy of Water-Soluble Fraction of Rhus semialata Gall Extract and Penta-O-Galloyl-β-D-Glucose on Mitigation of Hair Loss: An In Vitro and Randomized Double-Blind Placebo-Controlled Clinical Study

research A Novel Topical Compound Gel Loading Minoxidil and Tofacitinib for Treatment of Alopecia Areata: Formulation, Characterization, and In Vitro/In Vivo Evaluation

research Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study

research Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study

research Study on the regulatory effect of Ligusticum chuanxiong on inflammation of human dermal papilla cells in alopecia areata based on network pharmacology and in vitro experiment

research TỔNG QUAN VỀ SINH HỌC CỦA TÓC, MÔ HÌNH NGHIÊN CỨU VÀ ĐÁNH GIÁ KHẢ NĂNG MỌC LẠI TÓC TRÊN IN-VITRO VÀ IN-VIVO

research The Potential Teeth Bleaching and Halitosis Prevention Effects of Pediococcus inopinatus THK-30, a Kimchi-Derived Lactic Acid Bacterium: In Vitro Study

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVECs angiogenesis in vitro

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or placental tissue promoted HUVECs angiogenesis in vitro

research 681 Inhibition of STAT3, using Oenocarpus bataua vegetable oil, on in vitro model

research Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies

research Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

research Follicular penetration of nano-sized particulate FA-PLGA and the dye RhBITC in dorsal dog and rat skin, and porcine ear skin as an in vitro model for the human integument