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GlossaryInterleukin-17

protein that promotes inflammation in immune responses

Interleukin-17 (IL-17) is a type of protein known as a cytokine that plays a crucial role in the body's immune response by promoting inflammation. It is produced by a subset of T cells called Th17 cells and is involved in defending against infections, but excessive IL-17 activity is also linked to autoimmune diseases, such as psoriasis and rheumatoid arthritis.

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Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

research Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions

34 citations , January 2022 in “Frontiers in Immunology”

IL-25 helps heal diabetic wounds by improving blood vessel and skin cell functions.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research Detection of Serum Levels of Interleukins-17, 21, 6 and Tumor Necrosis Factor-α in Patients with Patchy Alopecia Areata and Their Association with Disease Severity

September 2025 in “Diseases”

Higher levels of certain proteins in the blood are linked to more severe patchy alopecia areata.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study

32 citations , October 2023 in “Biomedicines”

PCOS causes inflammation regardless of body weight.

research The immunopathogenesis of Alopecia Areata

2 citations , January 2020 in “Enlighten: Theses (The University of Glasgow)”

Alopecia areata is an autoimmune disease causing hair loss, and targeting macrophages may help treat it.

research Depressive Disorder and Dermatological Autoimmune Diseases

1 citations , May 2024 in “Journal of Clinical Medicine”

Depression and skin autoimmune diseases are linked, needing combined care for better treatment.

research Secukinumab-Induced Alopecia Areata Successfully Treated with Tofacitinib in a Patient with Palmoplantar Pustulosis

1 citations , October 2023 in “Clinical, cosmetic and investigational dermatology”

Tofacitinib improved hair loss and skin symptoms in a patient after secukinumab caused hair loss.

Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

research Study on the Efficacy and Potential Mechanism of Topical Shen Bai Hair Growing Decoction against Androgenetic Alopecia Based on Ultrahigh Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and RNA-seq

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research Advances in Cell-Mediated Drug Delivery for Dermatologic Diseases: Mechanisms and Current Applications

2 citations , November 2025 in “Pharmaceutics”

Cell-mediated drug delivery systems improve skin disease treatment by using living cells for precise, prolonged, and less toxic therapy.

Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium

10 citations , May 2020 in “Dermatology Research and Practice”

Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.

research Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3

8 citations , February 2015 in “Cellular immunology”

Deleting Snai2 and Snai3 causes fatal autoimmunity.

Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial

research Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial

November 2025 in “Journal of Multidisciplinary Healthcare”

Combining fire needle therapy with doxycycline improves severe acne more than doxycycline alone.

research Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

47 citations , September 2023 in “Pharmacological Reports”

Vitamins A, B3, C, D, and E can improve skin health and immunity.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

research Successful treatment of palmoplantar pustular psoriasis with brodalumab

9 citations , July 2018 in “European Journal of Dermatology”

Brodalumab effectively treated a man's severe hand and foot psoriasis.

research T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces

January 2023 in “Discovery immunology”

T cells and bacteria in the gut and skin help maintain health and protect against disease.

research Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

Red light exposure can slow aging in mice by improving fat metabolism.

research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

September 2025 in “Arthritis Research & Therapy”

BMS-470539 reduces skin fibrosis and inflammation.

Dormant Tumor Cells in Ret Transgenic Mouse Melanoma Model and Their Interaction with Memory T Cells

research Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury

10 citations , August 2014 in “PLoS ONE”

Hair follicles can help diagnose traumatic brain injury quickly and non-invasively.