research PHYTOCHEMICAL INVESTIGATIONS OF THE LEAVES AND FLOWERS OF HIBISCUS ROSA-SINENSIS L.
Hibiscus rosa-sinensis L. leaves and flowers contain various compounds with potential medicinal uses.
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120-150 / 1000+ resultsresearch Metabolomics analysis reveals metabolite diversity of the rare cliff plant Oresitrophe rupifraga Bunge
The rare cliff plant Oresitrophe rupifraga has diverse metabolites, with leaves rich in phenolic acids and rhizomes and bulblets high in terpenoids, aiding its growth and potential use.
research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes
Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.
research Anthocyanin as Colorectal Anticancer: A Brief Review
Anthocyanins from fruits and vegetables may help prevent and treat colorectal cancer safely.
research Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review
The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.
research Retinoids Modulate MITF: A Novel Mechanism in the Regulation of Melanogenesis
Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.
research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis
Blocking certain immune signals can reduce skin damage from radiation therapy.
research Auxin modulates root-hair growth through its signaling pathway in citrus
Auxin controls root-hair growth in citrus by affecting its signaling pathway.
research Screening of steroid 5-reductase inhibitory activity and total phenolic content of Thai plants
Ocimum basilicum L. and red Oryza sativa L. may help with hair loss and prostate issues.
research Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride
The research helps understand how finasteride works and aids drug development.
research Recent Progress in Health Benefits of Hederagenin and Its Glycosides
Hederagenin shows promise for cancer and inflammation treatment but needs modifications to improve effectiveness.
research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity
MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.
research Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment
Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.
research Accumulation of I131 by the skin and hair of animals and man
Radioiodine-131 significantly accumulates in skin and hair.
research Biosynthetic studies through feeding experiments in Eclipta prostrata (L.) L. hairy roots
The study found that in Eclipta prostrata roots, coumestans come from acetate and shikimate pathways, and phenylpropanoid is made only through the shikimate pathway.
research 5alpha-reductase inhibitors/finasteride.
research Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview
Hesperidin from orange peels is a promising natural ingredient for skincare due to its multiple beneficial properties.
research Preparation and Characterization of Rutin-loaded Nanophytosomes
Nanophytosomes can improve the delivery and effectiveness of herbal medicines like Rutin.
research Enzyme Inhibitors from Gorgonians and Soft Corals
Marine compounds from gorgonians and soft corals show promise for drug development, especially for chronic disorders.
research Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study
Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
research Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes
Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.
research Substantiation of technological parameters of the oil extract obtained from Urtica dioica roots based on the yield determination of phytosterols using capillary gas chromatography method
The best way to extract oil from Urtica dioica roots is by using corn oil, a 1:5 ratio of raw material to extract, extracting for 6 hours, and using the maceration method.
research Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach
New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.
research The effect of flavonoids on regenerated hair follicles with pigmentation
Certain flavonoids can improve the growth of pigmented hair in mice.
research Solubilization and Solid‐State Characterization of a Poorly Soluble 5‐α Reductase Inhibitor
GI197111X is best dissolved in Capmul MCM for trials.
research The extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro
research Melanogenesis‐promoting effect of Cirsium japonicum flower extract in vitro and ex vivo
Cirsium japonicum flower extract increases melanin production and could help treat depigmentation conditions.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research Therapeutic potential of Ishophloroglucin a from Ishige okamurae in androgenic alopecia: inhibition of 5α-reductase activity and activation of the Wnt/β-catenin signaling pathway in human dermal papilla cells
Ishophloroglucin A from Ishige okamurae may be a natural alternative for treating hair loss by inhibiting 5α-reductase and promoting hair growth.