18 citations
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April 2001 in “Bioorganic & Medicinal Chemistry Letters” The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.
January 2007 in “동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine” Biotae Orientalis extracts may help treat hair loss.
43 citations
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August 2010 in “Expert Opinion on Investigational Drugs” Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.
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October 2017 in “PubMed” Isotretinoin and acitretin may effectively stabilize the hairline in patients with frontal fibrosing alopecia.
26 citations
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June 2005 in “Journal of Molecular Endocrinology” Dutasteride is more efficient than finasteride, but individual results vary.
August 2024 in “Journal of Personalized Medicine” Tamsulosin increases the risk of floppy iris during eye surgery.
January 2018 in “Figshare” Ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata.
April 2022 in “Reactions Weekly”
11 citations
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April 2015 in “EBioMedicine” JAK inhibitors may help treat Alopecia Areata but need careful monitoring due to side effects.
June 2021 in “F1000Research” Plant-based compounds may offer safer prostate cancer treatment with fewer side effects.
Isotretinoin delays bone development in young rats.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” Jamogenin and other molecules may help treat hair loss by inhibiting 5-alpha reductase.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” Jamogenin and other compounds may help treat hair loss by inhibiting 5-alpha reductase.
5 citations
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November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.
17 citations
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December 2015 in “Bioorganic & Medicinal Chemistry” 3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.
1 citations
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March 1997 in “Journal of Chromatography B: Biomedical Sciences and Applications” Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.
June 1993 in “Current opinion in therapeutic patents” Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.
March 2018 in “Suez Canal University Medical Journal” New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.
The models can help find better inhibitors for conditions like baldness and prostate disorders.
Finasteride, a medication, is being re-evaluated for its effects and uses.
20 citations
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June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
7 citations
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August 2024 in “Journal of Cosmetic Dermatology” Isotretinoin effectively treats acne with low risk if dosed correctly.
August 2021 in “Revista Colombiana de Reumatología/Revista Colombiana de Reumatologia” Janus kinase inhibitors may effectively treat severe alopecia areata unresponsive to other treatments.
48 citations
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January 2005 in “Treatments in Endocrinology”
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January 2017 in “Chemical & Pharmaceutical Bulletin” Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
September 2023 in “Journal of the American Academy of Dermatology”
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June 2001 in “Bioorganic & Medicinal Chemistry” Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
18 citations
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January 1996 in “Gynecologic and obstetric investigation” The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.
May 1962 in “Zhurnal Fizicheskoi Khimii (U.S.S.R.) For English translation see Russ. J. Phys. Chem. (Engl. Transl.)” PCOS causes hormonal imbalances and health issues like infertility and heart disease.
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November 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” Oral tofacitinib can treat both psoriasis and alopecia universalis by normalizing inflammatory pathways.