January 2007 in “Bristol Research (University of Bristol)” Epidermolysis bullosa in UK calves is not caused by mutations in keratin genes.
Keratinocytes grew and migrated into hair follicle areas but disappeared after 15-20 days.
43 citations
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October 2006 in “Journal of Cell Science” Keratin 10 end domains may increase skin cancer risk by reducing cell death.
20 citations
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November 2003 in “American Journal Of Pathology” Fibroblasts from healthy donors can prevent changes seen in recessive epidermolysis bullosa simplex.
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September 2020 in “Open Biology” Better understanding of wound healing is needed to develop effective treatments for chronic wounds.
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July 2015 in “British Journal of Dermatology” Acute wounds heal well, but chronic wounds struggle due to ongoing inflammation and poor tissue repair.
303 citations
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October 2000 in “Nature” RXRα is crucial for hair growth and skin cell function.
149 citations
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June 2010 in “The FASEB journal” miR-31 regulates hair growth by controlling gene expression in hair follicles.
138 citations
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June 2004 in “Journal of Investigative Dermatology” Involucrin gene expression is controlled by specific proteins and signaling pathways.
137 citations
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April 2001 in “Journal of Clinical Investigation” Alopecia in these mice is caused by defective hair cycle communication due to missing vitamin D receptor function, not vitamin D levels.
112 citations
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January 2013 in “Experimental dermatology” Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.
99 citations
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January 2004 in “Progress in brain research” Neurotrophins are important for hair growth and could help treat hair loss.
70 citations
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December 2004 in “Proceedings of the National Academy of Sciences” BMP signaling affects hair color by interacting with the MC-1R pathway.
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January 2020 in “International Journal of Molecular Sciences” PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.
54 citations
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January 2007 in “The Journal of Steroid Biochemistry and Molecular Biology” Vitamin D receptor is essential for hair growth and preventing hair loss.
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February 2012 in “PloS one” Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
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August 2013 in “The Journal of experimental medicine/The journal of experimental medicine” Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
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November 2024 in “Scientific Reports” The new wound dressing speeds up healing and kills bacteria effectively.
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September 2011 in “PLOS ONE” Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.
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January 2022 in “Frontiers in Genetics” Aging reduces dermal sheath cells, affecting youthful skin appearance.
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July 2020 in “American journal of human genetics” Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.
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February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Plet-1 protein helps hair follicle cells move and stick to tissues.
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June 1993 in “The Journal of Cell Biology” The oncoprotein causes abnormal hair growth without increasing skin cancer risk.
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February 2010 in “The Journal of Steroid Biochemistry and Molecular Biology” Vitamin D receptor is crucial for healthy hair growth and preventing hair loss.
28 citations
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June 2021 in “Frontiers in immunology” A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.
25 citations
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March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
25 citations
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September 1995 in “Biochemistry and Cell Biology” High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.
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September 2019 in “Experimental cell research” BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.
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September 2014 in “PloS one” Thyroid hormone receptors are essential for hair growth and wound healing.
23 citations
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July 2022 in “Nature Cell Biology” Targeting THY1 can improve skin repair and healing.