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GlossaryLesional Skin

areas of skin showing visible abnormalities or damage

Lesional skin refers to areas of the skin that exhibit visible abnormalities or damage, such as rashes, sores, or other disruptions in normal skin structure. These lesions can result from various conditions, including infections, autoimmune diseases, or physical trauma, and are often the focus of medical examination and treatment.

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Study of the Behavior of Lesional and Nonlesional Skin of Canine Recurrent Flank Alopecia Transplanted to Athymic Nude Mice

research Study of the behaviour of lesional and nonlesional skin of canine recurrent flank alopecia transplanted to athymic nude mice

2 citations , July 2013 in “Veterinary dermatology”

Dog skin with hair loss, when transplanted to mice, regrew hair, suggesting the hair loss cause is likely body-wide, not skin-specific.

research 809 IL-13 protein concentrates in the epidermis of lesional and non-lesional skin of AD patients

July 2024 in “Journal of Investigative Dermatology”

IL-13 protein is much higher in the skin of atopic dermatitis patients than in healthy skin.

research Microarray Gene Expression Analysis of Lesional Skin in Canine Pemphigus Foliaceus

February 2024 in “Veterinary sciences”

Canine pemphigus foliaceus involves significant immune activity and shares similarities with human pemphigus.

research 496 Understanding the mechanism of action of secukinumab using lesional hidradenitis suppurativa skin organ culture

November 2024 in “Journal of Investigative Dermatology”

Secukinumab reduces immune activity in hidradenitis suppurativa skin.

research 1436 Lesional skin histology in drug-induced hypersensitivity syndrome: A single center 10-year experience of 37 patients

April 2023 in “Journal of Investigative Dermatology”

Interface dermatitis is the most common skin change in drug-induced hypersensitivity syndrome.

research Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases

15 citations , November 2015 in “International Journal of Dermatology”

Keratin 14 may be an autoantigen in autoimmune skin diseases.

research 1318 Both lesional and non-lesional skin from acne patients shows robust IL-17-skewing and upregulation of antimicrobial peptides

April 2018 in “Journal of Investigative Dermatology”

Acne patients' skin, both with and without lesions, shows a strong immune response and higher antimicrobial activity.

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

research Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris

2 citations , January 2024 in “Advances in Dermatology and Allergology”

The study investigates the expression of S100A7 and IL-17 in lichen planopilaris (LPP), a type of scarring alopecia. The research involved 14 participants and utilized a Zeiss Axio Imager A2 light microscope to evaluate tissue expression. Findings indicate that S100A7 and IL-17 may play a role in the pathogenesis of LPP, as their expression was significantly higher in LPP lesional skin compared to healthy controls. However, the expression of S100A4 did not show significant differences among LPP lesional skin, alopecia areata lesional skin, and normal skin. These results suggest a potential involvement of S100A7 and IL-17 in LPP's inflammatory processes.

research 413 DC-HIL+ myeloid-derived suppressor cells are elevated in the peripheral blood and lesional skin of cutaneous lupus patients

April 2018 in “Journal of Investigative Dermatology”

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

research 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

TYK2 inhibition may help treat alopecia areata by promoting hair growth and reducing immune response.

research 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo

July 2025 in “Journal of Investigative Dermatology”

Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.

research Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

48 citations , September 2020 in “Frontiers in Immunology”

Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.

research Aberrant inflammasome activation as a driving force of human autoimmune skin disease

3 citations , May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

research 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment

April 2023 in “Journal of Investigative Dermatology”

Acne patients have higher skin mTORC1 activity, which is reduced by isotretinoin treatment.

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

30 citations , July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

research Comparative efficacy of topical anthralin and intralesional triamcinolone in the treatment of alopecia areata.

7 citations , October 2012 in “PubMed”

Triamcinolone regrows hair better but relapses more than anthralin.

research 520 Body site heterogeneity and microbial diversity is lost in individuals with hidradenitis suppurativa

1 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

People with Hidradenitis Suppurativa have less diverse skin bacteria and different bacterial metabolism than healthy individuals.

research High throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in Alopecia Areata

1 citations , November 2018 in “immuneACCESS”

Expanded CD8+ T cells are linked to Alopecia Areata and may cause relapse after treatment.

research 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis

1 citations , July 2024 in “Journal of Investigative Dermatology”

TAK-279 effectively reduces psoriasis symptoms and is safe.

research Tolerance and efficacy of a new emollient barrier cream in pediatric and adult population with mild to moderate atopic dermatitis

June 2017 in “Journal of the American Academy of Dermatology”

The new cream is safe and effective for mild to moderate atopic dermatitis.

research The role of hsa‐miR‐193a‐5p as an important factor for control of inositol in alopecia areata

June 2024 in “Skin Research and Technology”

hsa-miR-193a-5p may help diagnose and treat alopecia areata.

research Symptom Checker (Lesional and Regional Dermatoses)

April 2018 in “Blackwell's Five‐Minute Veterinary Consult Clinical Companion”

The document provides a guideline to help identify skin conditions in small animals based on lesion characteristics.

research Associations Between Skin Microbiome and Metabolome in the Pathogenesis of Atopic Dermatitis Patients With Scalp Involvement

3 citations , January 2024 in “Allergy Asthma and Immunology Research”

Understanding the skin's bacteria and chemicals may help manage scalp issues in atopic dermatitis.

Multi-Modal Skin Atlas Identifies a Multicellular Immune-Stromal Community Associated with Disrupted Cornification and Specific T Cell Expansion in Atopic Dermatitis

research Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis

February 2026 in “Nature Communications”

A specific group of immune and skin cells may cause chronic inflammation in atopic dermatitis.

research The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls

220 citations , May 2017 in “JAMA dermatology”

Patients with hidradenitis suppurativa have a different skin microbiome compared to healthy people.

research Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients

March 2023

Higher TGF-β signaling may increase skin cancer risk in organ transplant recipients.

research 328 The transcription factor CEBPB is a novel hub gene and multi-functional disease driver in Psoriatic skin inflammation

November 2022 in “Journal of Investigative Dermatology”

ILC1-like cells can cause alopecia areata by themselves.

research Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

74 citations , October 2015 in “Experimental Dermatology”

Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.