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GlossaryLipoatrophy

localized loss of fat tissue causing skin indentations

Lipoatrophy is the localized loss of fat tissue, often resulting in indentations or depressions in the skin. This condition can be caused by repeated injections, certain medications, or autoimmune diseases, and it is commonly seen in people with diabetes who use insulin injections.

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research Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

218 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

research Coexistence of acquired localized hypertrichosis and lipoatrophy after lupus panniculitis

10 citations , April 2004 in “Journal of the American Academy of Dermatology”

Localized hair growth and fat loss may share a common cause in lupus panniculitis.

research A case report of lupus panniculitis-induced facial lipoatrophy successfully treated with injectable hyaluronic acid

January 2024 in “SAGE Open Medical Case Reports”

Injectable hyaluronic acid can effectively treat facial lipoatrophy from lupus panniculitis.

research Adipose and Hair Function: An aPPARent Connection

7 citations , February 2018 in “Journal of Investigative Dermatology”

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

research Berardinelli–Seip syndrome

February 2026 in “Endokrynologia Polska”

Early diagnosis and treatment are crucial for managing Berardinelli–Seip syndrome.

research Acquired progressive kinking of the hair in the setting of Parry-Romberg Syndrome

May 2015 in “Journal of The American Academy of Dermatology”

A woman with Parry-Romberg syndrome developed new curly hair on one side of her scalp, a condition not previously linked to the syndrome.

research Dermatological Issues in a Child with Diabetes Mellitus

January 2003 in “Springer eBooks”

Children with diabetes often have skin problems, which can be better managed with good blood sugar control.

research Alopecia Associated with Indinavir Therapy

38 citations , August 1999 in “New England journal of medicine/The New England journal of medicine”

Indinavir can cause hair loss and other skin problems.

research Management of Visible Granulomas Following Periorbital Injection of Poly-L-Lactic Acid

49 citations , July 2007 in “Ophthalmic Plastic and Reconstructive Surgery”

Surgical excision is an effective treatment for persistent nodules from poly-L-lactic acid injections.

research A rare primary subcutaneous panniculitis-like T-cell lymphoma with scalp involvement associated with lupus panniculitis

October 2021 in “European journal of cancer”

Repeated biopsies are crucial for managing lupus panniculitis when initial treatments fail.

research Anterior neck fat deposition in lipodystrophy syndrome; a new variant on a theme?

5 citations , August 2003 in “AIDS”

A new form of lipodystrophy in HIV patients causes neck fat buildup.

research Multiple sclerosis disease-modifying therapies: adverse effect surveillance and management

18 citations , March 2006 in “Expert Review of Neurotherapeutics”

The document concludes that managing side effects of MS therapies is crucial for treatment success and patient adherence.

research Lipedematous alopecia: an uncommon clinicopathologic variant of nonscarring but permanent alopecia

30 citations , May 2008 in “International Journal of Dermatology”

Lipedematous alopecia causes permanent hair loss due to increased scalp fat.

research Refinement of Technique in Injection Lipolysis Based on Scientific Studies and Clinical Evaluation

39 citations , March 2009 in “Clinics in plastic surgery”

Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.

research Lipedematous alopecia, an entity on the rise

June 2022 in “Authorea (Authorea)”

A 59-year-old woman was diagnosed with a rare hair loss condition called lipedematous alopecia.

research Presentation, diagnosis, and management options of lipedematous alopecia

9 citations , December 2018 in “JAAD case reports”

Lipedematous alopecia involves a thickened scalp and hair loss, with limited effective treatments available.

research Lipedema and lipedematous scalp: An overview

1 citations , July 2021 in “Journal of Skin and Sexually Transmitted Diseases”

Lipedema is a painful fat disorder in women that's hard to treat, often worsens with hormonal changes, and requires symptom-focused therapies.

research Rare Concurrence of Alopecia Areata in the Setting of the Lipedematous Scalp

September 2022 in “The American journal of dermatopathology/American journal of dermatopathology”

A patient with a thick scalp and hair loss was correctly diagnosed with alopecia areata and a thick scalp fat layer, not lipedematous alopecia, and regrew hair after treatment.

research Lipedematous scalp with lipedematous alopecia: A case report

May 2021 in “Our Dermatology Online”

A woman with a rare scalp condition causing a thick scalp and hair loss didn't improve with steroid treatment.

research Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature

2 citations , January 2019 in “Case Reports in Dermatology”

A 66-year-old woman's thick scalp and hair loss were confirmed as lipedematous alopecia, a rare condition possibly influenced by genetics, with no effective treatment known.

research Lipedematous alopecia of the scalp

35 citations , January 2006 in “Dermatology Online Journal”

Lipedematous scalp may be underdiagnosed and doesn't improve with finasteride.

research Atypical necrobiosis lipoidica of the face

7 citations , May 1978 in “Acta Dermato Venereologica”

A 36-year-old man had unusual skin lesions on his face without hair loss.

research Interest of Panax Ginseng and Albizia Julibrissin extracts to prevent age-related hair density reduction

August 2019 in “Journal of the American Academy of Dermatology”

Ginseng and Albizia extracts help prevent hair thinning with age.

research Necrobiosis Lipoidica

27 citations , December 1999 in “American Journal of Dermatopathology”

Necrobiosis lipoidica may need new criteria for accurate diagnosis due to similarities with another condition.

research 467 Prospective study of the metabolic effects of tumescent liposuction

April 2023 in “Journal of Investigative Dermatology”

Tumescent liposuction reduces waist and hip size but doesn't significantly change metabolic markers, though it may slightly improve blood pressure and certain protein levels.

research Distinguishing Lipedematous Scalp, Lipedematous Alopecia, and Diffuse Alopecia Areata

5 citations , January 2019 in “Skin appendage disorders”

The conclusion is that it's important to tell apart alopecia areata from lipedematous alopecia for proper treatment, as alopecia areata can be reversed.

research Avaliação de alterações estruturais envolvendo o surgimento de tecido adiposo em localizações anômalas e o deslocamento de glândulas crinas em três alopecias cicatriciais primárias linfocíticas

July 2024 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)”

Adipose tissue and eccrine gland displacement are common in certain alopecias but don't help differentiate between them.