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Did you mean Macrophage Polarization?

GlossaryMacrophage Polarization

process where immune cells change roles based on signals

Macrophage polarization refers to the process by which macrophages, a type of immune cell, change their functional state in response to different signals in their environment. They can adopt a pro-inflammatory state (M1) to fight infections or a healing state (M2) to repair tissues. This ability to switch roles is crucial for maintaining balance in the immune system and is important in conditions like infections, cancer, and autoimmune diseases.

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research Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

22 citations , August 2021 in “Frontiers in medicine”

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

research Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration

January 2026 in “Journal of Ethnopharmacology”

Cedrol promotes hair growth better than baricitinib by regulating immune cells.

Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

research Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages

2 citations , April 2023 in “Stem Cell Research & Therapy”

Tiny fat-derived particles can help repair soft tissues by changing immune cell types.

research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Reactive oxygen species (ROS) influence hair growth by causing DNA damage, cell death, and changes in immune cells.

Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

research Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

40 citations , March 2022 in “Small”

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

research DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration

January 2026 in “Journal of Dermatological Science”

DcR3 helps heal wounds and regrow hair by changing macrophages to a repair-focused type.

research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair

January 2026 in “Burns & Trauma”

NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.

research 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response

April 2024 in “Molecules/Molecules online/Molecules annual”

The composite sponge helps heal diabetic wounds by reducing inflammation and promoting new blood vessel growth.

research Flammulina velutipes polysaccharide boosts the anti-tumor immunity by reversing M1/M2 polarization through TLR4/NF-κB activation

January 2026 in “Food Science and Human Wellness”

Flammulina velutipes polysaccharide helps the immune system fight tumors by activating certain pathways.

research The impact of biomaterial characteristics on macrophage phenotypes in tissue engineering: a review

6 citations , April 2025 in “Plastic and Aesthetic Research”

Biomaterial characteristics can influence macrophages to promote healing and improve tissue regeneration.

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations , June 2018 in “Frontiers in Physiology”

ADM scaffolds help skin heal by promoting a healing-type immune response.

Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

research Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

61 citations , September 2020 in “Bioactive Materials”

A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.

research Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization

6 citations , September 2024 in “BMC Pulmonary Medicine”

Cepharanthine may help treat lung fibrosis by affecting certain immune cells.

research Macrophages are necessary for skin regeneration during tissue expansion

44 citations , January 2019 in “Journal of Translational Medicine”

Macrophages are essential for successful skin growth in reconstructive surgery.

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

research Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

18 citations , December 2021 in “Journal of Nanobiotechnology”

The nanofibers effectively treated infected diabetic wounds by killing bacteria and aiding wound healing without toxicity.

research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice

December 2021 in “Research Square (Research Square)”

M-CSF-stimulated myeloid cells can cause alopecia areata in mice.

research Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis

6 citations , June 2022 in “Frontiers in Bioengineering and Biotechnology”

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.