research 307 Dermatologic toxicities associated with chronic gamma-secretase inhibitor treatment for desmoid tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
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research Clinical perspectives on the age-related increase of immunosuppressive activity
Aging and chronic inflammation weaken the immune system, increasing cancer and infection risks.
research What does acne genetics teach us about disease pathogenesis?
Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
research Targeting lymphoid-derived IL-17 signaling to delay skin aging
Blocking IL-17 signaling may reduce skin inflammation and delay aging.
research Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris
New genetic factors linked to acne risk were discovered, highlighting the role of certain pathways and genes.
research NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research The Pathogenesis of Primary Cicatricial Alopecias
The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
research Regulatory T Cells: the Many Faces of Foxp3
Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
research Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
Spermidine helps protect against aging by preserving telomere length.
research Under Development JAK Inhibitors for Dermatologic Diseases
New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.
research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice
Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.
research Mucosal TLR5 activation controls healthspan and longevity
Activating TLR5 in the gut can extend lifespan and improve health in aged mice.
research Biomaterials for dermal substitutes
The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
research Impeding Glial Scarring Hyperplasia and Activating Axon Neogenesis via Immunomodulatory Microneedle Patch for Spinal Cord Repair
A new microneedle patch helps repair spinal cord injuries by reducing scarring and promoting nerve growth.
research Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities
miRNAs could help diagnose and treat gouty arthritis.
research Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
research Pathophysiology of the Behçet's Disease
Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.
research ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor
Removing the ROBO4 gene in mice reduces skin inflammation and hair loss by affecting certain inflammation pathways and gene expression.
research Scarless wound healing – a literature review
Fetal skin can heal without scarring, offering insights for new scar-reducing treatments.
research Evaluation of Hypoxia-Conditioned MSC Exosomes’ Effects on GM-CSF and IL-1α Expression in a Rat Model of Androgenic Alopecia
EH-MSCs may help treat hair loss by boosting regeneration and reducing inflammation.
research Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice
Salicylate helps wounds heal without scarring in mice.
research Telocytes: current methods of research, challenges and future perspectives
Telocytes have potential in therapy and tissue regeneration, but challenges in identification and cultivation remain.
research Association Between Urolithiasis and Hidradenitis Suppurativa: A Retrospective Cohort Study
People with hidradenitis suppurativa have a higher risk of kidney stones.
research The Role and Mechanism of Nanozymes in Burn Wound Healing
Nanozymes help heal burn wounds by fighting bacteria, reducing inflammation, and promoting blood vessel growth.
research The polycystic ovary syndrome: a position statement from the European Society of Endocrinology
The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.
research Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential
Wharton's jelly secretomes are best for promoting blood vessel growth.
research Baricitinib: From Rheumatoid Arthritis to COVID‐19
Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.
research Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate
Solanum nigrum shows promise for treating COVID-19 and its complications, but more research is needed.
research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome
The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
research Sprayable supramolecular hydrogel with minimalism for wilderness first aid: integration of mechanical performance and biofunctionality
The hydrogel speeds up wound healing and fights bacteria, making it great for emergency use.