research Mechanisms of tolerance and potential therapeutic interventions in Alopecia Areata
Targeting immune tolerance issues in Alopecia Areata could restore hair growth and maintain remission.
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research AI-driven biomaterial design: an intelligent closed loop from reverse design to biological response
AI improves biomaterial design by making it faster, cheaper, and more effective for personalized medicine.
research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.
research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth
Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
research Mechanisms of Submucosal Gland Morphogenesis in the Airway
LEF1 is essential for the development of airway glands and is regulated by the Wnt/ß-catenin pathway.
research Mechanism of PPARα agonist in alopecia areata
PPARα agonists may help treat alopecia areata by reducing inflammation.
research The cycling hair follicle as an ideal systems biology research model
The hair follicle is a great model for research to improve hair growth treatments.
research Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration
Chemotherapy can cause brain inflammation and damage, and understanding this process could help manage side effects.
research Exogen involves gradual release of the hair club fibre in the vibrissa follicle model
Hair sheds gradually from the follicle, with readiness to shed indicated by less attachment material.
research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome
Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia
The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia
Researchers created a mouse model of a type of rickets that does not cause hair loss.
research Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice
Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.
research Exploring caspase functions in mouse models
Caspases affect many cell functions and could help treat various diseases.
research Wound healing mechanism in Mongolian gerbil skin
Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.
research A Mouse Model for Conditional Expression of Activated β-Catenin in Epidermal Keratinocytes
Activated β-catenin affects hair growth and skin thickness, and changes are reversible.
research An appraisal of laboratory models of androgenetic alopecia: A systematic review
Better hair loss models needed for research.
research Medical Reasoning with Large Language Models: A Survey and MR-Bench
Large language models struggle with accurate clinical decision-making compared to real-world needs.
research Hair cluster detection model based on dermoscopic images
The new model detects hair clusters more accurately and efficiently, helping with early hair loss treatment and diagnosis.
research MECHANISM OF ACTION OF AVICENNIA MARINA HEARTWOOD EXTRACT AND AVICEQUINONE C ON HUMAN DERMAL PAPILLA CELLS ISOLATED FROM ANDROGENIC ALOPECIA PATIENTS
Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.
research GABAAreceptor modulation by neurosteroids in models of temporal lobe epilepsies
Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.
research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
research Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway
Cardamonin may help treat oral cancer by promoting cell death and stopping cancer cell growth.
research Data-driven strategies for drug repurposing: insights, recommendations, and case studies
Drug repurposing can speed up and reduce costs in drug discovery, especially for cancer treatment.
research A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals
The new skin model can predict how chemicals might cause skin allergies.
research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry
Rodent models of PCOS show some hormone changes similar to humans, but also have key differences.
research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
research Group-ICA Model Order Highlights Patterns of Functional Brain Connectivity
Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.
research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome
The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
research Teriflunomide and Its Mechanism of Action in Multiple Sclerosis
Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.