November 2015 in “European Journal of Inflammation” Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.
346 citations
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April 2020 in “Frontiers in Oncology” EMT and metabolic pathways help cancer cells resist treatment and spread.
54 citations
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May 2015 in “Endocrinology” Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.
51 citations
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September 2020 in “Cell Metabolism” Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.
2 citations
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January 1997 in “Principles of Medical Biology” Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Blocking both main energy pathways can stop hair follicle stem cell-induced skin cancer growth.
12 citations
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September 1999 in “The journal of experimental zoology/Journal of experimental zoology” Prolactin levels do not control the start of winter fur growth in mink.
June 2024 in “Current Developments in Nutrition” Diet changes can improve skin health by altering the immune response and skin microbiome.
3 citations
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January 2021 in “Journal of Research in Medical Sciences” Certain medications can impact metabolic syndrome, with some improving conditions like high blood sugar and others having no effect.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” Red light exposure can slow aging in mice by improving fat metabolism.
59 citations
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May 2017 in “Scientific reports” ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.
38 citations
,
February 2021 in “Journal of Investigative Dermatology” Aging slows wound healing due to weaker cells and immune response.
Iron levels affect sleep apnea severity in people with hair loss, especially women.
185 citations
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June 2011 in “Molecular and cellular endocrinology” Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
November 2022 in “Journal of Investigative Dermatology” Butyrate helps hair grow longer, improves hair cell health, increases pigment production, and boosts hair's natural defenses.
Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.
1 citations
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July 2023 in “Chinese Medicine” Shi-Bi-Man, a Traditional Chinese Medicine, helps grow hair by boosting lactic acid metabolism and activating hair follicle stem cells.
519 citations
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February 2020 in “Inflammation and Regeneration” RANKL is crucial for bone health, immune function, and other body processes.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Human hair follicles have a unique way of using energy and might use the Cori cycle; blocking CCR5 could help treat hair loss.
218 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
2 citations
,
January 2025 in “动物学研究” YAP1 helps fat cell formation by influencing the Hippo pathway.
Problems with arginine processing in hair follicles might contribute to common hair loss, and arginine supplements could help treat it.
31 citations
,
January 2011 in “Dermato-endocrinology” Melatonin protects skin against UV damage by regulating various cellular processes.
28 citations
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January 2018 in “Biochemical Society Transactions” Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.
1 citations
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April 2006 in “International Journal of Oncology” Lysocellin helps stop cell damage from etoposide and may prevent hair loss.
January 2026 in “Biomolecules” TSC22D genes are key in metabolic diseases and cancer, offering potential as treatment targets.
2 citations
,
May 2025 in “Frontiers in Immunology” Ursolic acid may help develop new anti-inflammatory drugs by affecting immune cells.
52 citations
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September 2018 in “International Journal of Molecular Sciences” Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.
17 citations
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July 2018 in “Environmental and Experimental Botany” Silencing NtNCED3-2 gene in tobacco reduces drought tolerance and impairs growth.
February 2025 in “International Journal of Molecular Sciences” Maternal melatonin improves offspring hair growth by affecting specific proteins and pathways.