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Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.
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research Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
Type-2 immunity may influence skin diseases and could be targeted for treatment.
research 649 Gut microbiota plays a role in the development of alopecia areata
The gut microbiome affects the development of alopecia areata.
research Aligned membranes regulate wound healing via MMP12 secreted by macrophages
Aligned membranes improve wound healing by reducing scars and promoting skin regeneration.
research The effect of 5-α reductase inhibitor on Th1, Th2, and Th17 cell-related inflammatory response in BPH
Finasteride reduces some inflammation in BPH but not all.
research Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages
Soluble CD83 speeds up wound healing and reduces scarring.
research Nanotechnology-Driven Antioxidants and Immunomodulators for Polycystic Ovary Syndrome (PCOS) Therapy
Nanotechnology offers promising new treatments for PCOS by reducing inflammation and oxidative stress.
research Familial 1q22 microduplication associated with psychiatric disorders, intellectual disability and late-onset autoimmune inflammatory response
A specific genetic change is linked to mental disorders, intellectual disability, and possibly autoimmune disease in a family.
research A case of sarcoidal foreign body reaction to permanent makeup: the involvement of M2 macrophages
Steroid injections improved symptoms and hair regrowth in a woman with a reaction to permanent makeup.
research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium
Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.
research Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia
A microneedle patch can help regrow hair by restoring immune balance in hair follicles.
research The Identification of Bipotent Dermal Stem Cells and The Role of Anti-Inflammatory Macrophages During Hair Follicle Regeneration
Bipotent dermal stem cells and specific macrophages are crucial for hair regrowth and regeneration.
research Alarmin Cytokines as Central Regulators of Cutaneous Immunity
Alarmin cytokines are key in controlling skin immunity and inflammation.
research 202 MicroRNAs in the pathogenesis of male pattern baldness
Different levels of microRNAs in different parts of the scalp can cause male pattern baldness.
research Scalable fabrication, compartmentalization and applications of living microtissues
Continuous microfluidic processes can help scale up microtissue production for industrial and clinical use.
research Gut microbes and skin disease, gut-brain-skin axis: A review
Balancing gut microbes and managing stress can help improve skin conditions like eczema and acne.
research Clinical Snippets
Skin has a larger surface area than thought, certain skin cells improve skin flap survival, better trials for skin conditions in children are needed, Stevens-Johnson syndrome rates vary by age and race, and better skin barrier function may reduce inflammation in the elderly.
research 528 Serotonin modulation improves cutaneous wound healing
Serotonin helps wounds heal faster.
research Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system.
Alpha-melanocyte-stimulating hormone helps manage skin inflammation and protect against UV damage.
research Autoimmune skin disease pathogenesis: a chronological immune cascade and multi-hit model
Autoimmune skin diseases result from genetic and environmental factors disrupting immune checkpoints.
research Skin Microbiome and Dermatitis: Focusing on Two Distinct Skin Diseases, Atopic Dermatitis and Androgenetic Alopecia
Understanding skin microbes and sebum can help manage atopic dermatitis and hair loss.
research Photobiomodulation therapy
Photobiomodulation therapy can reduce pain and inflammation and help heal tissues, but more research is needed to improve its effectiveness and safety.
research Melanocortins in fibroblast biology – current update and future perspective for dermatology
α-MSH may help treat skin inflammation and fibrosis.
research Epithelial–mesenchymal transition in cutaneous fibrosis disease: from mechanisms to therapy
EMT plays a key role in skin fibrosis and offers new therapy targets.
research 1455 Cutaneous wounds healed at the cost of overall fitness in the aged Balb/C mouse model
Older mice healed wounds better but lost more weight and might have weaker immune systems afterward.
research Small Molecule Inhibitors and Inflammatory Skin Diseases
New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.
research Impaired Notch‐MKP ‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology
Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.
research Common pathologic pathways: A single prescription dream?
The conclusion suggests that treatments targeting root causes of chronic diseases may be developed by focusing on gene expression and lifestyle factors.
research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition
Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.
research Improved cutaneous wound healing after intraperitoneal injection of alpha‐melanocyte‐stimulating hormone
Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.